Antiproliferative and genotoxic activities in L929 and HeLa cell lines, mutagenic effects in Salmonella strains of novel benzoxazole derivatives

Basit Öğe Kaydı
dc.contributor.authorÖksüzoğlu, Emine
dc.contributor.authorFoto, Egemen
dc.contributor.authorZilifdar, Fatma
dc.contributor.authorErtan-Bolelli, Tuğba
dc.contributor.authorBolelli, Kayhan
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:22:00Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:22:00Z
dc.date.issued2016
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractSome novel fused heterocyclic compounds of 2,5-disubstituted-benzoxazole derivatives, which were previously synthesized by our group, were investigated for their mutagenic properties on Salmonella typhimurium TA 98 and TA 100 strains, cytotoxic activity in L929 and HeLa cell lines by Sulforhodamine B (SRB) cytotoxicity test, and genotoxic potentials in the comet assay. By using Ames/Salmonella assay in the presence of S9 fraction, B22 (5-nitro-2-(p-nitrobenzyl)benzoxazole) was found to be mutagenic in both S. typhimurium TA98 and TA100 strains at all tested doses. IC50 values which were evaluated by SRB cytotoxicity assay revealed that B11 (2-(p-nitrobenzyl)benzoxazole) (IC50 = 99.16 µM) was the most anti-proliferative compound on HeLa cancer cells. Compounds were also tested for their genotoxicity by using comet assay, and it was found that all the compounds had DNA-damaging genotoxic activity on HeLa cells. The comet assay results showed that B11 produced DNA damage at lower concentrations than the other compounds tested on HeLa cancer cells. The results obtained from all the tests suggest that B11 could be a good candidate as a new anticancer agent. © 2016, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.
dc.identifier.endpage2224en_US
dc.identifier.issn0326-2383
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage2216en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12451/2430
dc.identifier.volume35en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherColegio de Farmaceuticos de la Provincia de Buenos Aires
dc.relation.ispartofLatin American Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmes/Salmonella Test
dc.subjectAnticancer Drugs
dc.subjectBenzoxazole Derivatives
dc.subjectComet Assay
dc.subjectDNA Damage-Genotoxicity
dc.subjectSRB Cytotoxicity Assay
dc.titleAntiproliferative and genotoxic activities in L929 and HeLa cell lines, mutagenic effects in Salmonella strains of novel benzoxazole derivatives
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
oksuzoglu-emine-2016.pdf
Boyut:
344.14 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu