Synthesis, structural characterization, and cytotoxic activity of new spirocyclic octachlorocyclotetraphosphazenes

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dc.authoridHokelek, Tuncer -- 0000-0002-8602-4382
dc.contributor.authorIşıklan, Muhammed
dc.contributor.authorSayın, Levent
dc.contributor.authorSonkaya, Ömer
dc.contributor.authorHökelek, Tuncer
dc.contributor.authorTürk, Mustafa
dc.contributor.authorOğuztüzün, Serpil
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:30:19Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:30:19Z
dc.date.issued2016
dc.departmentAksaray Teknik Bilimler Meslek Yüksekokulu
dc.description.abstractOctachlorocyclotetraphosphazene, N4P4Cl8, (1) was reacted with N, N-dibenzylethylenediamine to synthesize partially substituted monospiro- (2), dispiro- (5) and tetraspirocyclotetraphosphazene (8) derivatives. The reactions of 2 and 5 with excess pyrrolidine and morpholine produced fully substituted pyrrolidino (3 and 6) and morpholino (4 and 7) spirocyclotetraphosphazenes. The structures of the compounds were determined with 1D (H-1, C-13, P-31, and DEPT) NMR, 2D (HSQC) NMR, ESI-MS, FTIR, and elemental analysis. The solid-state structures of 6 and 7 were examined by X-ray crystallography. In 7, intramolecular C-H...O hydrogen bonds link the molecules into centrosymmetric dimmers. The cytotoxic activity of all the compounds against human cervix carcinoma cell lines (HeLa) was investigated. The study showed that these compounds exert limited cytotoxic, apoptotic and necrotic effects on HeLa cancer cell lines.
dc.description.sponsorshipKirikkale University, Scientific Research Projects Coordination Unit [2005/19]; Hacettepe University, Scientific Research Unit [0202602002]
dc.description.sponsorshipThe authors gratefully acknowledge the "Kirikkale University, Scientific Research Projects Coordination Unit" Grant No. 2005/19 and "Hacettepe University, Scientific Research Unit" Grant No. 0202602002 for financial support.
dc.identifier.doi10.1080/10426507.2016.1160240
dc.identifier.endpage1222en_US
dc.identifier.issn1042-6507
dc.identifier.issn1563-5325
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage1216en_US
dc.identifier.urihttps://doi.org/10.1080/10426507.2016.1160240
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6263
dc.identifier.volume191en_US
dc.identifier.wosWOS:000382941000006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofPhosphorus Sulfur and Silicon and the Related Elements
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCyclotetraphosphazenes
dc.subjectSpirophosphazenes
dc.subjectCrystal Structure
dc.subjectSpectroscopy
dc.subjectHeLa Cancer Cell Line
dc.subjectCytotoxicity
dc.titleSynthesis, structural characterization, and cytotoxic activity of new spirocyclic octachlorocyclotetraphosphazenes
dc.typeArticle

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