How important is group size in selecting rats for experimental studies? evolution with zootechnical and biochemical findings

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dc.contributor.authorKandemir, Özge
dc.contributor.authorGenç, Murat
dc.date.accessioned2022-09-29T10:32:01Z
dc.date.available2022-09-29T10:32:01Z
dc.date.issued2022
dc.departmentTeknik Bilimler Meslek Yüksekokulu
dc.description.abstractIn this study, which was conducted to investigate the growth performances of male Sprague-Dawley rats grown in different group sizes and changes that occurred in their oxidative statuses, 60 male 4-week-old Sprague-Dawley rats were used. Two different cages with different dimensions were used, and 4 rats were put into each of the small cages, while 6 were put into each of the large cages. The trial was carried out with 6 replications. The rats were weighed each week for one month on the same day and at the same hour, and the average cage values were recorded. It was determined that the live weights showed a regular increase in both groups, and the growth performances did not differ based on group size. Group size was highly effective on the antioxidant components of the rats, and growing the rats in more crowded environments led to oxidative stress by changing their Total Antioxidant Capacity (TAC) (p<0.05), Total Oxidant Capacity (TOC) (p<0.05), Nitric Oxide (NO) (p<0.001), glutathione (GSH) (p<0.0001) and malondialdehyde (MDA) (p<0.001) levels. In the light of the data obtained, it was concluded that, when dense rat breeding is carried out to achieve more production from a unit area, even though no changes occur in the morphological structures of the animals, their oxidant balance is disrupted. This prevents obtaining accurate and reliable data in scientific studies. Consequently, it was determined that group size is a criterion that needs to be kept in mind in selection of rats to be used in scientific studies, and the appropriate group size should be provided for these animals.
dc.identifier.endpage6749en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue6Aen_US
dc.identifier.startpage6744en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9699
dc.identifier.volume31en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherParlar Scientific Publications
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGroup Size
dc.subjectSprague-Dawley
dc.subjectGrowth Performance
dc.subjectOxidative and Nitrosative Stress
dc.titleHow important is group size in selecting rats for experimental studies? evolution with zootechnical and biochemical findings
dc.typeArticle

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