Synthesis and in-vitro antimicrobial activity of novel aminophosphinic acids containing cyclobutane and 1,3-thiazole

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dc.authoridorek, cahit -- 0000-0002-3854-1537
dc.contributor.authorKoparır, Pelin
dc.contributor.authorKaraarslan, Muhsin
dc.contributor.authorÖrek, Cahit
dc.contributor.authorKoparır, Metin
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:29:44Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:29:44Z
dc.date.issued2011
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThe compounds {[4-(3-methyl-3-aryl(mesityl-phenyl-tetralino)cyclobutyl)-1,3-thiazol-2-yl]amino}(aryl)methyl-phosphinic acids 2a-l were prepared by condensation of 2-amino-4-(3-aryl(mesityl-phenyl-tetralino)-3-methylcyclobutyl)thiazoles 1a-c with various aromatic aldehydes and hypophosphorous acid through a one-pot reaction. The characterizations of these compounds were obtained by elemental analyses, infrared (IR) spectra, and H-1, C-13, and P-31 NMR (nuclear magnetic resonance) techniques. The synthesized compounds were tested in vitro against one Gram-positive and two Gram-negative bacterial strains, one mycobacterial strain, and a fungus Candida albicans. Compound 2f showed significant activity against Staphylococcus aureus, whereas the others had no remarkable activity on this strain. Compound 2g was found to be more active than the others against Mycobacterium fortuitum at an MIC (minimum inhibitory concentration) value of 32 mu g/mL. The antibacterial and antifungal activities of 2a-l were also compared with various standard drugs.
dc.identifier.doi10.1080/10426507.2011.604660
dc.identifier.endpage2376en_US
dc.identifier.issn1042-6507
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage2368en_US
dc.identifier.urihttps://doi.org/10.1080/10426507.2011.604660
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6202
dc.identifier.volume186en_US
dc.identifier.wosWOS:000299727800013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofPhosphorus, Sulfur and Silicon and the Related Elements
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAminophosphinic Acids
dc.subjectCyclobutane
dc.subjectThiazole
dc.titleSynthesis and in-vitro antimicrobial activity of novel aminophosphinic acids containing cyclobutane and 1,3-thiazole
dc.typeArticle

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