Prognostic value of glucose-to-potassium ratio and other biomarkers in in-hospital cardiac arrest

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dc.authorid0000-0001-8050-4433
dc.authorid0000-0003-2295-3243
dc.authorid0000-0001-8410-5552
dc.authorid0000-0003-0950-0477
dc.authorid0000-0003-3407-1942
dc.authorid0000-0002-5629-3143
dc.authorid0000-0002-6320-9667
dc.authorid0000-0001-9210-914X
dc.contributor.authorVişneci, Emin Fatih
dc.contributor.authorDemirci, Osman Lütfi
dc.contributor.authorTekin, Fatih Cemal
dc.contributor.authorKadıoğlu, Emine
dc.contributor.authorMutlu, Hüseyin
dc.contributor.authorGenç, Murat
dc.contributor.authorBulut, Bensu
dc.contributor.authorAkkan Öz, Medine
dc.contributor.authorYazıcı, Ramiz
dc.date.accessioned2025-07-25T08:30:29Z
dc.date.available2025-07-25T08:30:29Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractThis study aimed to evaluate the prognostic value of the serum glucose/potassium ratio (GPR) for sustained return of spontaneous circulation (ROSC) and 30-day mortality in patients with in-hospital cardiac arrest (IHCA). Methods: Patients aged 18 years or older who underwent cardiopulmonary resuscitation (CPR) for cardiac arrest in the emergency department (ED) were included. Routine laboratory parameters were obtained from the first blood sample collected during CPR in the ED. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were calculated by dividing the absolute number of neutrophils and platelets, respectively, by the absolute number of lymphocytes. The GPR was calculated as serum glucose divided by potassium levels. Results: The 30-day mortality rate was 82.2% (n = 291). Multivariate logistic regression analysis identified lactate, NLR, PLR and GPR as independent predictors of mortality. Among these markers, lactate exhibited the highest predictive power for mortality, with an area under the curve (AUC) of 0.817, compared to NLR (AUC: 0.676), PLR (AUC: 0.679) and GPR (AUC: 0.688). The optimal cut-off values for predicting mortality were 7.83 for lactate (sensitivity: 75.3%, specificity: 89.4%), 1.68 for NLR (sensitivity: 78.8%, specificity: 71.7%), 199.26 for PLR (sensitivity: 76.4%, specificity: 92.3%) and 57.81 for GPR (sensitivity: 71.8%, specificity: 84.1%). Conclusions: Our findings suggest that GPR is a promising prognostic marker for predicting mortality in patients with IHCA.
dc.identifier.doi10.22514/sv.2025.097
dc.identifier.endpage68
dc.identifier.issn1334-5605 / 1845-206X
dc.identifier.issue7
dc.identifier.startpage62
dc.identifier.uri10.22514/sv.2025.097
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13588
dc.identifier.volume21
dc.identifier.wosWOS:001528319700007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorMutlu, Hüseyin
dc.institutionauthoridh0000-0002-1930-3293
dc.language.isoen
dc.publisherMRE Press
dc.relation.ispartofSigna Vitae
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIn-hospital Cardiac Arrest
dc.subjectMortality
dc.subjectGlucose/potassium Ratio
dc.subjectEmergency Department
dc.titlePrognostic value of glucose-to-potassium ratio and other biomarkers in in-hospital cardiac arrest
dc.typeArticle

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