Cross-linker engineering of hydrogel enables photothermal therapy and controlled drug release

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dc.contributor.authorAlgı, Melek Pamuk
dc.contributor.authorSarıgöl, Rumeysa
dc.date.accessioned2024-04-18T05:52:23Z
dc.date.available2024-04-18T05:52:23Z
dc.date.issued2023
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractHerein we disclose an approach that provides access to multifunctional polymeric hydrogels by cross-linker engineering. To this purpose, a new squaraine dye, Sq1, was synthesized. It was found that Sq1 could generate hyperthermia upon irradiation with NIR (808 nm) light. More importantly, PAAm hydrogels incorporating Sq1 as a covalent cross-linker (Sq1@PAAm) can be obtained successfully. Delightfully, cross-linker-engineered PAAm hydrogels can be used as an efficient photosensitizer for photothermal therapy. In vitro studies with human melanoma cell line (SK-MEL-30/An1) cell lines show that Sq1@PAAm hydrogels can eliminate more than 70% of cancer cells. Finally, methotrexate (MTX) as a model drug is loaded into the hydrogel, and release behavior is evaluated. Notably, sustained MTX release was possible by irradiating the Sq1@PAAm hydrogel. Overall, we have successfully shown that the cross-linker engineering of hydrogel enables photothermal therapy.
dc.identifier.doi10.1016/j.jddst.2023.104993
dc.identifier.issn1773-2247
dc.identifier.scopusqualityQ1
dc.identifier.urihttps:/dx.doi.org10.1016/j.jddst.2023.104993
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11637
dc.identifier.volume89en_US
dc.identifier.wosWOS:001105957300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEditions de Sante
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDrug Delivery
dc.subjectHydrogel
dc.subjectPhotothermal Therapy
dc.subjectSquaraine
dc.titleCross-linker engineering of hydrogel enables photothermal therapy and controlled drug release
dc.typeArticle

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