Aligned bacterial PHBV nanofibrous conduit for peripheral nerve regeneration

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dc.authoridBayram, Cem -- 0000-0001-8717-4668; Temucin, Cagri Mesut -- 0000-0003-0127-6861; Korkusuz, Petek -- 0000-0002-7553-3915
dc.contributor.authorDemirbilek, Murat
dc.contributor.authorSakar, Mustafa
dc.contributor.authorKarahaliloğlu, Zeynep
dc.contributor.authorErdal, Ebru
dc.contributor.authorYalçın, Eda
dc.contributor.authorBozkurt, Gökhan
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorBilgiç, Elif
dc.contributor.authorTemuçin, Çağri Mesut
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:14:59Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:14:59Z
dc.date.issued2015
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThe conventional method of peripheral nerve gap treatment is autografting. This method is limited. In this study, an aligned nanofibrous graft was formed using microbial polyester, Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). The regenerative effect of the graft was compared with that of autografting in vivo. To determine the regenerative effect, rats were assessed with sciatic nerve functional index, electromyographic evaluation, and histological evaluation. Results found in this study include PHBV grafts stimulated progressive nerve regeneration, although regeneration was not comparable with that of autografting. We conclude that the study results were promising for aligned bacterial polymeric grafts for peripheral nerve regeneration.
dc.identifier.doi10.3109/21691401.2013.875033
dc.identifier.endpage251en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue4en_US
dc.identifier.pmid24450753
dc.identifier.scopusqualityQ1
dc.identifier.startpage243en_US
dc.identifier.urihttps://doi.org/10.3109/21691401.2013.875033
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4238
dc.identifier.volume43en_US
dc.identifier.wosWOS:000359796700005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofArtificial Cells Nanomedicine And Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAligned Scaffold
dc.subjectBacterial PHBV
dc.subjectPeripheral Nerve Regeneration
dc.subjectRegenerative Medicine
dc.titleAligned bacterial PHBV nanofibrous conduit for peripheral nerve regeneration
dc.typeArticle

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