Research of sulfadiazine using subcritical water and water plus alcohol mixtures as the solvent: Solubility and thermodynamic property

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dc.authoridAkay, Sema -- 0000-0001-8887-6653
dc.contributor.authorAkay, Sema
dc.contributor.authorKayan, Berkant
dc.contributor.authorDu Cunbin
dc.contributor.authorWang, Jiang
dc.contributor.authorYang, Yu
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:17:09Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:17:09Z
dc.date.issued2018
dc.departmentFen-Edebiyat Fakültesi
dc.description.abstractSulfonamides are drugs extensively used for the treatment of infections caused by gram-positive and gram negative microorganisms, some fungi, and certain protozoa. They are also used in agriculture to prevent and treat diseases in livestock. Sulfadiazine is a member of the sulfonamide family. In this study, the solubility of sulfadiazine in pure subcritical water and water + alcohol mixtures has been measured using a homemade system at (298 to 403) K under a constant pressure of 5.1 MPa. Our results revealed that the solubility of sulfadiazine was enhanced with increasing temperature and higher percentage of ethanol or propanol in water. Modified Apelblat equation and CNIBS/R-K model were used to correlate and predict the solubility of sulfadiazine in pure subcritical water as well as in subcritical water + alcohol mixtures. The predicted solubility values are in good correlation with the experimental data. In addition, "Apparent thermodynamic analysis" was applied to calculate the dissolution enthalpy property of the solution process.
dc.description.sponsorshipScientific Research Project Unit (BAP) of Aksaray University [2016/038]
dc.description.sponsorshipThe authors gratefully thank the Scientific Research Project Unit (BAP) of Aksaray University (2016/038) for the financial support of this work.
dc.identifier.doi10.1016/j.molliq.2018.01.044
dc.identifier.endpage276en_US
dc.identifier.issn0167-7322
dc.identifier.issn1873-3166
dc.identifier.scopusqualityQ1
dc.identifier.startpage270en_US
dc.identifier.urihttps://doi.org/10.1016/j.molliq.2018.01.044
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4708
dc.identifier.volume253en_US
dc.identifier.wosWOS:000426411500032
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Liquids
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSulfadiazine
dc.subjectSolubility
dc.subjectSubcritical Water
dc.subjectThermodynamic Model
dc.subjectThermodynamic Property
dc.titleResearch of sulfadiazine using subcritical water and water plus alcohol mixtures as the solvent: Solubility and thermodynamic property
dc.typeArticle

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