Diagnostic role of serum testican and ubiquitin levels in patients with head trauma

dc.authorid0000-0001-9210-914X
dc.contributor.authorYazıcı, Ramiz
dc.contributor.authorBasa Kalafat, Ayşe Fethiye
dc.contributor.authorMutlu, Hüseyin
dc.contributor.authorSarı, Eyüp
dc.contributor.authorKalafat, Utku Murat
dc.contributor.authorAtik, Dilek
dc.contributor.authorCander, Başar
dc.date.accessioned2024-11-14T08:51:37Z
dc.date.available2024-11-14T08:51:37Z
dc.date.issued2024
dc.departmentTıp Fakültesi
dc.description.abstractWe aimed to determine if testican-1 and ubiquitin can serve as early indicators for diagnosing worsening clinical course (presence of intraparenchymal pathology) and mortality in patients with moderate traumatic brain injury (TBI).In this study, we conducted an observational and prospective study in the Emergency Department (ED) of a tertiary care hospital. The department admitted an average of 25,000 patients per month between October 2020 and March 2021. We focused on patients over 18 years old with moderate traumatic brain injury (Glasgow coma score (GCS): 9–13). We compared the prognostic values of blood testican and ubiquitin levels with Receiver Operating Characteristic (ROC) analysis for intracranial pathologies resulting from head trauma. Additionally, we used logistic regression analysis to compare the effectiveness of these markers in diagnosing intraparenchymal injury. The study included a total of 89 patients, with 45 in the case group (moderate TBI) and 44 in the healthy control group. It was found that levels of ubiquitin and testican levels were significantly higher in patients with intraparenchymal pathology (p = 0.048, p = 0.046, respectively). The cut-off point for detecting intraparenchymal pathology was 161.3 pg/mL for testican (Area under curve (AUC): 0.810; min: 0.654; max: 0.965, p = 0.002) and 44.42 ng/mL for Ubiquitin (AUC: 0.863; min: 0.727; max: 1.000, p < 0.001). High testican-1 and ubiquitin levels were independent markers for intraparenchymal pathology in moderate head trauma.
dc.identifier.doi10.22514/sv.2024.131
dc.identifier.endpage112en_US
dc.identifier.issn1334-5605
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage106en_US
dc.identifier.urihttps:/dx.doi.org/10.22514/sv.2024.131
dc.identifier.urihttps://hdl.handle.net/20.500.12451/12640
dc.identifier.volume20en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPharmamed Mado Ltd
dc.relation.ispartofSigna Vitae
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiomarkers
dc.subjectDiagnostics
dc.subjectModerate Traumatic Brain Injury
dc.subjectTestican
dc.subjectUbiquitin
dc.titleDiagnostic role of serum testican and ubiquitin levels in patients with head trauma
dc.typeArticle

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