Effects of curcumin and tannic acid on the aluminum- and lead-induced oxidative neurotoxicity and alterations in NMDA receptors

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dc.authoridTuzmen, Nalan -- 0000-0001-9863-7023;
dc.contributor.authorTüzmen, Münire Nalan
dc.contributor.authorYücel, Nilgün Candan
dc.contributor.authorKalburcu, Tülden
dc.contributor.authorDemiryas, Nazan
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:27:27Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:27:27Z
dc.date.issued2015
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractExposure to aluminum (Al) and lead (Pb) can cause brain damage. Also, Pb and Al exposure alters N-methyl-D-aspartate receptor (NMDAR) subunit expression. Polyphenols such as tannic acid and curcumin are very efficient chelator for metals. The effects of curcumin and tannic acid (polyphenols) on Al3+- and Pb2+-induced oxidative stress were examined by investigating lipid peroxidation (LPO) levels, antioxidant enzyme activities, acetyl cholinesterase (AChE) activity and also NMDA receptor subunits 2A and 2B concentrations in the brain tissue of rats subchronically. Rats were divided into seven groups as control, Al, Pb, aluminum-tannic acid treatment (AlT), aluminum-curcumin treatment (AlC), lead-tannic acid treatment (PbT) and leadcurcumin treatment (PbC). After 16 weeks of treatment, LPO levels in the brain and hippocampus were higher in Al3+-exposed rats than that of Pb2+-exposed group. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in brain tissue of Al- and Pb-exposed rats increased significantly compared with control, while catalase (CAT) and AChE activities decreased. It was observed that metal exposure affected NR2A concentrations more than NR2B concentrations and also that polyphenol treatments increased these receptor protein concentrations.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK Grant) [104T404]
dc.description.sponsorshipThis study was financially supported by the The Scientific and Technological Research Council of Turkey (TUBITAK Grant No. 104T404).
dc.identifier.doi10.3109/15376516.2014.997947
dc.identifier.endpage127en_US
dc.identifier.issn1537-6516
dc.identifier.issn1537-6524
dc.identifier.issue2en_US
dc.identifier.pmid25496357
dc.identifier.scopusqualityQ2
dc.identifier.startpage120en_US
dc.identifier.urihttps://doi.org/10.3109/15376516.2014.997947
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5866
dc.identifier.volume25en_US
dc.identifier.wosWOS:000352488200006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofToxicology Mechanisms and Methods
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMetals
dc.subjectNMDAR
dc.subjectOxidative Stress
dc.subjectPolyphenols
dc.titleEffects of curcumin and tannic acid on the aluminum- and lead-induced oxidative neurotoxicity and alterations in NMDA receptors
dc.typeArticle

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