Curcumin-loaded silk fibroin e-gel scaffolds for wound healing applications

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dc.contributor.authorKarahaliloğlu, Zeynep
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:30:01Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:30:01Z
dc.date.issued2018
dc.departmentSabire Yazıcı Fen-Edebiyat Fakültesi
dc.description.abstractRecently, silk fibroin gel systems (e-gel), formed with weak electric fields have been prepared for various tissue-engineering applications such as neural, cartilage and bone. Here, we demonstrated the effectiveness of an electroresponsive silk fibroin (SF) hydrogel, which is a 3-D scaffold formed and used as a wound dressing material. SEM studies revealed that the curcumin (CUR)-loaded SF (CUR-SF) consisted of a 3-D porous structure with a porosity percent of 80% and a swelling ratio over 100%. Colony forming unit assay confirmed that CUR-SF e-gel scaffolds produced a reduction in viable bacteria compared to bare SF scaffolds. In vitro studies performed with immortalized human keratinocyte (HaCaT) indicated no toxicity of CUR-loaded SF e-gel scaffolds to healthy cells. Taking all the results together, it was suggested that the CUR-SF e-gel scaffolds could improve the wound healing activity in comparison to SF without curcumin and be potentially used as a wound dressing material.
dc.description.sponsorshipHacettepe University
dc.description.sponsorshipThe author would like to thank Murat Demirbilek and Eda Yalcin for technical assistance in cytocompatibility assays. The author would also like to thank Hacettepe University for support.
dc.identifier.doi10.1080/10667857.2018.1432171
dc.identifier.endpage287en_US
dc.identifier.issn1066-7857
dc.identifier.issn1753-5557
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage276en_US
dc.identifier.urihttps://doi.org/10.1080/10667857.2018.1432171
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6232
dc.identifier.volume33en_US
dc.identifier.wosWOS:000428679700005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofMaterials Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntibacterial
dc.subjectCurcumin
dc.subjectElectrogelation
dc.subjectSilk Fibroin
dc.subjectWound Dressing
dc.titleCurcumin-loaded silk fibroin e-gel scaffolds for wound healing applications
dc.typeArticle

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