Effect of In Vitro Digestion on Anticancer and Antioxidant Activity of Phenolic Extracts From Latex of Fig Fruit (Ficus carica L.)

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dc.contributor.authorYeniocak, Salih
dc.contributor.authorKaraduman Yeşildal, Tuğçe
dc.contributor.authorArslan, Mustafa Enes
dc.contributor.authorToraman, Gizem Cansu
dc.contributor.authorYücetepe, Aysun
dc.date.accessioned2025-04-22T12:05:34Z
dc.date.available2025-04-22T12:05:34Z
dc.date.issued2025
dc.departmentMühendislik Fakültesi
dc.description.abstractIn this study, changes in total phenolic content (TPC), phenolic profile, and antioxidant activity and anticancer activity against cervix cancer and colorectal cancer cell lines of phenolic extracts of black and white fig (Ficus carica L.) latex (milk) were investigated during in vitro gastrointestinal digestions for the first time. The findings indicated that the in vitro digestion process exerted a significant effect on TPC of the phenolic extract from white fig milk (WFM-PE) and phenolic extract from black fig milk (BFM-PE), and TPC tended to decrease after in vitro digestion (p < 0.05). As consistent with these findings, antioxidant activity (by the CUPRAC method) of the samples decreased (p < 0.05) during in vitro digestion. The IC50 value of the undigested BFM-PE was significantly lower than that of the undigested WFM-PE (p < 0.05). The undigested and the digested WFM-PE and BFM-PE did not show any cytotoxic activity against normal cells. However, anticancer activity of WFM-PE on cervix and colorectal cancer cell lines (p < 0.05) and anticancer activity of BFM-PE against colorectal cancer cell lines decreased after in vitro digestion (p < 0.01). On the other hand, the dominant phenolic was catechin hydrate and was syringic acid.
dc.identifier.doi10.1002/cbdv.202401624
dc.identifier.issn16121872
dc.identifier.issue4
dc.identifier.pmid39590517
dc.identifier.scopus2-s2.0-85212491344
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://dx.doi.org/10.1002/cbdv.202401624
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13115
dc.identifier.volume22
dc.identifier.wos001380608400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.institutionauthorYeniocak, Salih
dc.institutionauthorKaraduman Yeşildal, Tuğçe
dc.institutionauthorArslan, Mustafa Enes
dc.institutionauthorToraman, Gizem Cansu
dc.institutionauthorYücetepe, Aysun
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofChemistry and Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnticancer Activity
dc.subjectAntioxidant Activity
dc.subjectFig Latex 1
dc.subjectIn Vitro Digestion 4
dc.subjectPhenolics 5
dc.titleEffect of In Vitro Digestion on Anticancer and Antioxidant Activity of Phenolic Extracts From Latex of Fig Fruit (Ficus carica L.)
dc.typeArticle

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