Saponin loaded montmorillonite-human serum albumin nanocomposites as drug delivery system in colorectal cancer therapy

Basit Öğe Kaydı
dc.authoridBOZDOGAN, BETUL -- 0000-0003-1546-3895
dc.contributor.authorAkbal, Öznur
dc.contributor.authorVural, Tayfun
dc.contributor.authorMalekghasemi, Soheil
dc.contributor.authorBozdoğan, Betül
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:15:10Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:15:10Z
dc.date.issued2018
dc.departmentFen-Edebiyat Fakültesi
dc.description.abstractThis study reports the synthesis and application of new saponin (SAP)-loaded montmorillonite-human serum albumin (Mt-HSA) nanocomposites (NCs) as an anticancer drug delivery agent. When the biodegradable and biofriendly HSA was combined with Mt., which possesses excellent mucoadhesive properties, the resulting NCs could pass through the gastrointestinal barrier easily. SAP-Mt-HSA NCs were prepared by a modified desolvation technique in which ethanol and glutaraldehyde (GA) were used as precipitating and crosslinking agents, respectively. The efficacy of these NCs was assessed in a colorectal cancer cell line (DLD-1) as an in-vitro gastrointestinal model and L929 fibroblast cells as a healthy cell model. The release profile of SAP and the cytotoxic effect and cellular uptake of NCs were evaluated. The results clearly demonstrated that SAP-Mt-HSA NCs can induce dose-dependent cancer cell death with little or no toxicity toward healthy cells.
dc.identifier.doi10.1016/j.clay.2018.09.021
dc.identifier.endpage222en_US
dc.identifier.issn0169-1317
dc.identifier.issn1872-9053
dc.identifier.scopusqualityQ1
dc.identifier.startpage214en_US
dc.identifier.urihttps://doi.org/10.1016/j.clay.2018.09.021
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4311
dc.identifier.volume166en_US
dc.identifier.wosWOS:000449135300025
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofAPPLIED CLAY SCIENCE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectSaponin
dc.subjectMontmorillonite
dc.subjectHuman Serum Albumin
dc.subjectNanocomposites
dc.subjectDLD-1 cell
dc.subjectCancer Treatment
dc.titleSaponin loaded montmorillonite-human serum albumin nanocomposites as drug delivery system in colorectal cancer therapy
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
akbal-oznur-2018.pdf
Boyut:
1.81 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu