Evaluation of oxidative status and inflammatory changes in naturally occurring canine visceral leishmaniasis

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dc.contributor.authorKontaş Aşkar, Tünay
dc.contributor.authorAşkar, Şinasi
dc.contributor.authorBüyükleblebici, Olga
dc.contributor.authorGüzel, Murat
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:25:23Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:25:23Z
dc.date.issued2019
dc.departmentVeteriner Fakültesi
dc.description.abstractThe aim of the study is to determine the oxidative stress and inflammatory changes in naturally occurring canine visceral leishmaniasis (CVL). A total of 30 dogs, comprising 10 clinically healthy and 20 dogs with leishmaniasis were enrolled in this study. The diagnosis of canine visceral leishmaniasis was performed by the immune fluorescence antibody test with antibody titter ?1:128 and lymph node smear examination. In blood samples of dogs with visceral leishmaniasis, levels of malondialdehyde, total antioxidant capacity, glutathione, nitric oxide, myeloperoxidase, adenosine deaminase and cytokines (TNF-alpha, IL-1ß) were determined and compared with the healthy controls. Significantly high levels of plasma malondialdehyde, nitric oxide, myeloperoxidase, adenosine deaminase and cytokines and significantly low levels in total antioxidant capacity and glutathione levels were found in dogs with leishmaniasis when compared with the healthy controls. According to the result of this study, oxidative stress and inflammatory changes occur in CVL. And this is the first report for myeloperoxidase (MPO) activity in CVL. Therefore investigation of this enzyme activity in dogs with leishmaniasis may be used for the diagnosis and inflammatory changes in dogs with VL. Copyright 2019 Zoological Society of Pakistan.
dc.identifier.doi10.17582/journal.pjz/2019.51.1.301.306
dc.identifier.endpage306en_US
dc.identifier.issn0030-9923
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage301en_US
dc.identifier.urihttps://dx.doi.org/10.17582/journal.pjz/2019.51.1.301.306
dc.identifier.urihttps://hdl.handle.net/20.500.12451/3041
dc.identifier.volume51en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Punjab (new Campus)
dc.relation.ispartofPakistan Journal of Zoology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDog
dc.subjectInflammatory Changes
dc.subjectLeishmaniasis
dc.subjectOxidative Stress
dc.titleEvaluation of oxidative status and inflammatory changes in naturally occurring canine visceral leishmaniasis
dc.typeArticle

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