Solubility of Salicylic Acid in Some (Ethanol + Water) Mixtures at Different Temperatures: Determination, Correlation, Thermodynamics and Preferential Solvation
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Dosyalar
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Equilibrium mole fraction solubility of salicylic acid in nine aqueous-ethanolic mixtures, as well as in neat water and neat ethanol, was determined at seven temperatures from T = (293.15 to 323.15) K. Salicylic acid solubility in these mixtures was adequately correlated with well-known correlation/prediction methods based on Jouyban-Acree model. Apparent thermodynamic quantities, i.e. Gibbs energy, enthalpy, and entropy, for the dissolution and mixing processes, were computed by means of the van’t Hoff and Gibbs equations. The enthalpy–entropy compensation plot of enthalpy vs. Gibbs energy of dissolution was not linear exhibiting positive slopes from neat water to the mixture of w 1 = 0.30 and from the mixture of w 1 = 0.50 to neat ethanol indicating enthalpy-driven drug transfer processes but negative in the interval of 0.30 < w 1 < 0.50 indicating entropy-driven drug transfer processes from more polar to less polar solvent systems. Moreover, by using the inverse Kirkwood–Buff integrals it is observed that salicylic acid is preferentially solvated by water molecules in water-rich mixtures but preferentially solvated by ethanol molecules in those mixtures of 0.24 < x 1 < 1.00.
Açıklama
Anahtar Kelimeler
(Ethanol + water) Mixtures, Jouyban–Acree Model, Preferential Solvation, Salicylic Acid, Solubility, Solution Thermodynamics
Kaynak
International Journal of Thermophysics
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
44
Sayı
8
