Preparation and characterization of papaverine-loaded poly[(R)-3- hydroxybutyrate] membranes to be used in the prevention of vasospasm

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dc.contributor.authorGüven, Eylem
dc.contributor.authorGüven, Eşref Oğuz
dc.contributor.authorBayram, Cem
dc.contributor.authorKazak, Osman Nuri
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:23:58Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:23:58Z
dc.date.issued2010
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.descriptionPubMed ID: 21502032
dc.description.abstractThe objective of this study is the preparation and characterization of poly[(R)-3-hydroxybutyrate] (PHB) membrane loaded with a vasodialative agent (i.e., papaverine hydrochloride) as a blood vessel coverage strip to be used in the prevention of undesired vascular vasospasm. Papaverine-loaded PHB membranes were especially designed to act locally and provide an efficient, long term, and sustained prevention of vasospasm at the site of the newly created vascular anastomosis without any systemic vasodilation effect of the papaverine, which may be life-threatening for the patient. The membranes were prepared by gelation of PHB followed by solvent casting. PHB membranes were characterized in terms of morphology, chemical structure, swelling behavior, in vitro drug release, degradation, and blood compatibility studies as in vitro coagulation tests. Activated partial thromboplastin time, prothrombin time, and fibrinogen concentration were measured by blood coagulation assays. Investigated and evaluated parameters for in vitro drug release, degradation, and in vitro coagulation studies were the concentration of PHB and drug content. Similar effective parameters were used for swelling behavior studies (i.e., concentration of PHB and drug content). Drug release, swelling behavior, degradation, and in vitro coagulation of the membranes were found to be influenced by these parameters. Obtained results showed that papaverine-loaded PHB membranes provide an efficient and advantegous means for the prevention of vasospasm during vascular anastomosis as a local application. ©PDA, Inc. 2010.
dc.identifier.endpage326en_US
dc.identifier.issn1079-7440
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage316en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12451/2849
dc.identifier.volume64en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofPDA Journal of Pharmaceutical Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBlood Compatibility
dc.subjectCoagulation
dc.subjectDegradation
dc.subjectPapaverine Hydrochloride
dc.subjectPolyhydroxybutyrate Membrane
dc.subjectVasospasm
dc.titlePreparation and characterization of papaverine-loaded poly[(R)-3- hydroxybutyrate] membranes to be used in the prevention of vasospasm
dc.typeArticle

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