Cancers and benign processes on (68) Ga PSMA PET-CT imaging other than prostate cancer
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wolters Kluwer Medknow Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background Imaging plays an important role in the evaluation of prostate cancer patients. In recent years, much attention has been focused on gallium 68 prostate-specific membrane antigen positron emission tomography-computed tomography ( (68) Ga PSMA PET-CT) in prostate cancer patients and has been widely used for staging, restaging, and therapy response for these patients. The aim of this study was to report (68) Ga PSMA PET-CT in other cancers and benign processes incidentally detected on (68) Ga PSMA PET-CT in patients with prostate cancer. Materials and Methods A total of 600 (68) Ga PSMA PET-CT scans were performed for initial staging, restaging, detection of suspected recurrence, and therapy response in prostate cancer patients between December 2018 and June 2020. A total of 38 patients with histopathologically proven prostate cancer were included in the current study with other malignancies and benign processes. Mainly histopathology in most of cases and clinical and radiological follow-up in few cases after PET/CT scanning served as the standard of reference. Results A total of 38 patients (age range: 52-85 years; mean age: 68.6) with prostate cancer final histopathology results were included in the study. A total of 51 lesion sites were evaluated in 38 patients. Forty-one lesion regions of these 51 regions were based on histopathological diagnosis, whereas 10 of them were based on clinical follow-up and conventional radiological follow-up as differential criteria. Thirty of 51 lesion regions were evaluated as malignant and 21 were benign lesions. The most common (68) Ga PSMA ligand avid malignancy was lung adenocarcinoma (6/38). Conclusions Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein and mainly expressed in prostate epithelium. (68) Ga PSMA PET-CT imaging is very sensitive and specific imaging modality in prostate cancer patients. However, other malignancies and some benign processes may also have (68) Ga PSMA ligand avidity and some prostate cancer metastases may imitate other malignancies.
Açıklama
Anahtar Kelimeler
68Ga PSMA PET-CT, Benign Processes, Other Malignancies, Lung Cancer, Colon Cancer, Gastric Tumor, Multiple Myeloma
Kaynak
World Journal of Nuclear Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
21
Sayı
2
