Potential protective effect of hesperidin (Vitamin P) against hlyphosate-induced spermatogenesis damage in male rats: biochemical and histopathological findings on reproductive parameters

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dc.authorid0000-0002-7586-0895
dc.authorid0000-0003-4838-1597
dc.authorid0000-0001-6170-1706
dc.contributor.authorGüngör, Şükrü
dc.contributor.authorKırıkkulak, Murat
dc.contributor.authorDenk, Barış
dc.contributor.authorGülhan, Mehmet Fuat
dc.contributor.authorGüleş, Özay
dc.contributor.authorBudak, Duygu
dc.contributor.authorİnanç, Muhammed Enes
dc.contributor.authorAvdatek, Fatih
dc.contributor.authorYeni, Deniz
dc.contributor.authorTaşdemir, Umut
dc.date.accessioned2024-11-14T11:28:41Z
dc.date.available2024-11-14T11:28:41Z
dc.date.issued2024
dc.departmentTeknik Bilimler Meslek Yüksekokulu
dc.description.abstractThe aim of this study was to investigate the effectiveness of hesperidin (HES) on testicular histopathological changes, biochemical changes, and semen characteristics in rats exposed to glyphosate (GLP). The control group was given a normal diet devoid of GLP and HES, the HES group was given 100 mg/kg/day HES with the normal diet, the GLP group was given GLP at the LD50/10 dose of normal feed, which was 787.85 mg/kg/day, and the GLP + HES group was given normal feed containing 787.85 mg/kg/day LD50/10 dose of GLP in addition to 100 mg/kg/day HES. GLP administration reduced sperm motility, sperm plasma membrane integrity, glutathione levels, and total antioxidant levels in the testicular tissues of rats. Moreover, it caused an increase in right testis and left epididymis weights, abnormal sperm counts, malondialdehyde levels, total oxidant status, and DNA damage. The HES treatment showed curative effects on these parameters. Furthermore, HES was effective in lessening the histopathological damage that was caused by GLP. The results showedthat HES protects spermatological parameters and DNA integrity, improves antioxidant defenses, and lowers the damage and lipid peroxidation caused by GLP in testicular tissue.
dc.identifier.doi10.3390/life14091190
dc.identifier.issn2075-1729
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ1
dc.identifier.urihttps:/dx.doi.org/10.3390/life14091190
dc.identifier.urihttps://hdl.handle.net/20.500.12451/12643
dc.identifier.volume14en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofLife-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectGlyphosate Toxicity
dc.subjectHesperidin
dc.subjectTestis
dc.subjectHistopathology
dc.subjectSpermatozoa
dc.titlePotential protective effect of hesperidin (Vitamin P) against hlyphosate-induced spermatogenesis damage in male rats: biochemical and histopathological findings on reproductive parameters
dc.typeArticle

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