Electrochemical testosterone biosensor based on pencil graphite electrode electrodeposited with copper oxide nanoparticles

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dc.contributor.authorBozdoğan, Betül
dc.date.accessioned2023-09-27T12:16:26Z
dc.date.available2023-09-27T12:16:26Z
dc.date.issued2023
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractAccurately monitoring the blood levels of testosterone (TST) in a sensitive, simple, and rapid manner is of paramount importance for the diagnosis and treatment of various medical conditions, as well as for controlling pharmaceutical quality and facilitating doping detection. TST, the primary male sex hormone, plays a crucial role in facilitating human physical performance, protein synthesis, and the development of muscle mass. Consequently, TST and its analogues are frequently abused by athletes as performance-enhancing steroid in order to increase muscle mass and enhance their performance. The use of such steroids is strictly prohibited to guarantee fair play. In this study, we employed a pencil graphite electrode that was electrochemically modified with CuO nanoparticles (CuONPs) for determination of TST. The electrode response was significantly enhanced by approximately fourfold compared to the unmodified pencil graphite electrode (PGE) when electrodeposition CuONPs onto PGE surface was performed at a potential of ?0.6 V for 200 s. The success of modification was confirmed through morphological analysis using scanning electron microscopy and energy-dispersive x-ray spectroscopy. Using square wave adsorptive stripping voltammetry analysis in Britton-Robinson buffer at pH 6.0, we demonstrated that the proposed sensor exhibited sensitivity to detect TST within a linear range of 5-200 nM. The detection limit of sensor was calculated 4.6 nM (1.32 ng ml?1). The sensor platform developed for the accurate, sensitive, and specific determination of TST holds tremendous potential for the development of point-of-care devices and their integration into lab-on-a-chip research.
dc.identifier.doi10.1088/1361-6501/ace126
dc.identifier.issn0957-0233
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ1
dc.identifier.urihttps:/dx.doi.org10.1088/1361-6501/ace126
dc.identifier.urihttps://hdl.handle.net/20.500.12451/10985
dc.identifier.volume34en_US
dc.identifier.wosWOS:001018653600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInstitute of Physics
dc.relation.ispartofMeasurement Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdsorptive Stripping Voltammetry
dc.subjectCopper Oxide Nanoparticle
dc.subjectElectrodeposition
dc.subjectPencil Graphite Electrode
dc.subjectSquare Wave Voltammetry
dc.subjectTestosterone
dc.titleElectrochemical testosterone biosensor based on pencil graphite electrode electrodeposited with copper oxide nanoparticles
dc.typeArticle

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