Is galectin-3 a biomarker, a player-or both-in the presence of coronary atherosclerosis?

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dc.contributor.authorAksan, Gökhan
dc.contributor.authorGedikli, Ömer
dc.contributor.authorKeskin, Kudret
dc.contributor.authorNar, Gökay
dc.contributor.authorİnci, Sinan
dc.contributor.authorYıldız, Süleyman Sezai
dc.contributor.authorKaplan, Özgür
dc.contributor.authorSoylu, Korhan
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:22:01Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:22:01Z
dc.date.issued2016
dc.departmentTıp Fakültesi
dc.descriptionPubMed ID: 26912009
dc.description.abstractAtherosclerosis is a complex process mediated by leukocytes, macrophages and various inflammatory markers. Galectin-3 is secreted by activated macrophages and is involved in cardiac fibrosis, cardiac remodeling, and inflammation. The present study aimed to determine the relationship between the presence and severity of coronary artery disease (CAD) and serum galectin-3 levels. The study included 82 patients with CAD confirmed via coronary angiography and 82 healthy participants as control group. Angiographic CAD was defined as ?50% luminal diameter stenosis of at least one major epicardial coronary artery. The severity of CAD was determined by the Gensini score; and the serum galectin-3 levels were measured via ELISA. Serum galectin-3 levels were significantly higher in the patient group with CAD than in the control group (12.96±4.92 vs 5.52±1.9ng/mL, p<0.001). In the correlation analysis, serum galectin-3 showed significant correlation with the Gensini score (r=0.715, p<0.001), number of diseased vessels (r=0.752, p<0.001) and serum hs-CRP level (r=0.607, p<0.001). In addition, multivariate logistic regression analysis showed that the serum galectin-3 levels were significant and independent predictors of the presence of angiographic CAD (OR=3.933, 95% CI 2.395 to 6.457; p<0.001). In the present study, the serum galectin-3 levels were higher in the patients with CAD than in healthy controls. Also, serum galectin-3 levels showed a significant positive correlation with the severity of CAD. An increased serum galectin-3 level may be considered an important activator and a marker of the atherosclerotic inflammatory process in CAD.
dc.identifier.doi10.1136/jim-2015-000041
dc.identifier.endpage767en_US
dc.identifier.issn1081-5589
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage764en_US
dc.identifier.urihttps://dx.doi.org/10.1136/jim-2015-000041
dc.identifier.urihttps://hdl.handle.net/20.500.12451/2435
dc.identifier.volume64en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.relation.ispartofJournal of Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAtherosclerosis
dc.subjectCoronary Artery Disease
dc.subjectInflammation
dc.titleIs galectin-3 a biomarker, a player-or both-in the presence of coronary atherosclerosis?
dc.typeArticle

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