Serum zonulin levels are higher among children with autism spectrum disorders and correlated with social impairment

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dc.authorid0000-0002-6128-0136
dc.authorid0000-0002-8964-9513
dc.authorid0000-0003-4795-5413
dc.authorid0000-0002-6250-5093
dc.contributor.authorKara, Halil
dc.contributor.authorAçıkel, Sadettin Burak
dc.contributor.authorÇetinkaya, Miray
dc.contributor.authorTuncer, Sibel Çiğdem
dc.date.accessioned2021-12-02T06:12:46Z
dc.date.available2021-12-02T06:12:46Z
dc.date.issued2021
dc.departmentTıp Fakültesi
dc.description.abstractZonulin is a protein that affects the integrity of intercellular connections in the intestines. It has been emphasized that autoimmune diseases as well as neurodevelopmental disorders, for example autism spectrum disorder (ASD), may occur through alterations in intestinal permeability and blood-brain barrier. We aimed to investigate the gastrointestinal permeability of individuals with ASD by determining serum zonulin levels and their relationship to symptom severity. Methods: Twenty-five ASD patients and 19 controls were included. Serum zonulin levels were measured by enzyme-linked immunosorbent assay kits. Clinical severity was assessed by the Childhood Autism Rating Scale (CARS), and social skills of the control group were evaluated by the Conners’ Parents and Teacher’s Rating Scales-Revised/Long Forms (CPRS-CTRS). Results: Mean zonulin levels were significantly higher in the ASD group and positively correlated with CARS scores. After regression analysis, serum zonulin levels predicted CARS total scores. We could not find any significant correlation between zonulin levels and CPRS-CTRS sociability subscale scores in the control group. Conclusion: The positive correlation between serum zonulin levels and ASD severity may require precaution for impaired intestinal permeability in clinical practice, especially for the cases in which sociability is severely impaired. However, it is too early to state that intestinal permeability has a role in the etiology of ASD. Further studies involving specific autism subgroups, and samples with certain dietary differences are needed.
dc.identifier.doi10.5152/alphapsychiatry.2021.21152
dc.identifier.endpage256en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage250en_US
dc.identifier.urihttps:/dx.doi.org/10.5152/alphapsychiatry.2021.21152
dc.identifier.uri13026631
dc.identifier.urihttps://hdl.handle.net/20.500.12451/8859
dc.identifier.volume22en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCukurova University
dc.relation.ispartofAnadolu Psikiyatri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAutistic Disorder
dc.subjectEpithelium
dc.subjectHaptoglobins
dc.subjectPsychosocial Functioning
dc.titleSerum zonulin levels are higher among children with autism spectrum disorders and correlated with social impairment
dc.typeArticle

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