Selective cholesterol adsorption by molecular imprinted polymeric nanospheres and application to GIMS

Basit Öğe Kaydı
dc.authoridTuzmen, Nalan -- 0000-0001-9863-7023
dc.contributor.authorİnanan, Tulden
dc.contributor.authorTüzmen, Nalan
dc.contributor.authorAkgöl, Sinan
dc.contributor.authorDenizli, Adil
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:28:17Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:28:17Z
dc.date.issued2016
dc.departmentTeknik Bilimler Meslek Yüksekokulu
dc.description.abstractMolecular imprinted polymers (MIPs) are tailor-made materials with selective recognition to the target. The goals of this study were to prepare cholesterol imprinted polymeric nanospheres (CIPNs) and optimize their adsorption parameters and also to use CIPNs for adsorption of cholesterol (CHO), which is an important physiological biomacromolecule, from gastrointestinal mimicking solution (GIMS). Pre-polymerization complex was prepared using CHO as template and N-methacryloylamido-(L)-phenylalanine methyl ester (MAPA). This complex was polymerized with 2-hydroxyethyl methacrylate (HEMA). CHO was removed by MeOH and tetrahydrofuran (THF). Adsorption studies were performed after chacterization studies to interrogate the effects of time, initial concentration, temperature, and ionic strength on CHO adsorption onto CIPNs. Maximum adsorption capacity (714.17 mg/g) was higher than that of cholesterol imprinted polymers in literature. Pseudo-second-order kinetics and Langmuir isotherm fitted best with the adsorption onto CIPNs. 86% of adsorbed cholesterol was desorbed with MeOH:HAc (80:20, v/v) and CIPNs were used in adsorption-desorption cycle for 5-times with a decrease as 12.28%. CHO analogues; estron, estradiol, testosterone, and progesterone were used for competitive adsorption. The relative selectivity coefficients of CINPs for cholesterol/estron and cholesterol/testosterone were 3.84 and 10.47 times greater than the one of non-imprinted polymeric nanospheres (NIPNs) in methanol, respectively.
dc.description.sponsorshipDokuz Eylul University, Turkey [2012-KBFEN-107]
dc.description.sponsorshipThis study was financially supported by the Scientific Research Projects Coordination of Dokuz Eylul University, Turkey (Project number: 2012-KBFEN-107).
dc.identifier.doi10.1016/j.ijbiomac.2016.07.007
dc.identifier.endpage460en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid27411294
dc.identifier.scopusqualityQ1
dc.identifier.startpage451en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2016.07.007
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6015
dc.identifier.volume92en_US
dc.identifier.wosWOS:000386402900054
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCholesterol
dc.subjectBiomacromolecule
dc.subjectImprinting
dc.subjectGastrointestinal Mimicking Solution
dc.subjectSelectivity
dc.titleSelective cholesterol adsorption by molecular imprinted polymeric nanospheres and application to GIMS
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
inanan-tulden-2016.pdf
Boyut:
1.82 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu