Effects of acetylsalicylate overdose on lipopolysaccharide-induced lung injury in rats: the role of the VEGF

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dc.contributor.authorAkyüz, Fahrettin
dc.contributor.authorAydın, Özlem
dc.contributor.authorAydın, Tayfun
dc.contributor.authorTekin, Neslihan
dc.contributor.authorTemel, Halide Edip
dc.contributor.authorBurukoğlu, Dilek
dc.contributor.authorAral, Erinç
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:20:07Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:20:07Z
dc.date.issued2012
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractAim: Vascular endothelial growth factor production is decreased depending on the alveolar epithelial cell damage. Acute over expression of vascular endothelial growth factor in lung tissue contributes to the formation permeability. Excessive doses of acetylsalicylate (ASA) may induce pulmonary edema by increasing pulmonary vascular permeability. In this study, the effects of acetylsalicylate overdoses were evaluated on bronchoalveolar lavage fluid levels of vascular endothelial growth factor in the presence of lipopolysaccharide-induced lung injury in rats. Materials and Methods: Lung injury was induced by intraperitoneal injection of lipopolysaccharide (LPS). Rats were divided into six different sets consisting of 7 rats each for control, ASA-300, ASA-500, LPS, LPS+ASA-300 and LPS+ASA-500 series. ASA, 300 mg and 500 mg/kg doses were given by gavage. Acetylsalicylate was given 24 hours after lipopolysaccharide injection in LPS+ASA groups. Rats were sacrificed 6 hours after acetylsalicylate administration and bronchoalveolar lavage was performed. Results: In bronchoalveolar lavage fluid, vascular endothelial growth factor, matrix metalloproteinase-2 and nitric oxide levels were increased in group of ASA-500, and were decreased in groups of LPS+ASA. In addition, plasma salicylate half-life was prolonged in LPS+ASA groups. Conlusion: Lipopolysaccharide increases the time of being metabolized of acetylsalicylate. The lung tissue damage increases due to vascular endothelial growth factor, matrix metalloproteinase-2 and nitric oxide related mechanisms and recovery period is affected adversely. Also in humans, severe toxic effects on the lung tissue that can be generated by 300 and 500 mg/kg acetylsalicylate doses in rats showed less toxic effect.
dc.identifier.doi10.5505/tjb.2012.02411
dc.identifier.endpage238en_US
dc.identifier.issn0250-4685
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org/10.5505/tjb.2012.02411
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5061
dc.identifier.volume37en_US
dc.identifier.wosWOS:000314288600002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherTurkish Biochem Soc
dc.relation.ispartofTurkish Journal of Biochemistry-Türk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcetylsalicylate
dc.subjectLipopolysaccharide
dc.subjectLung Injury
dc.subjectVascular Endothelial Growth Factor
dc.titleEffects of acetylsalicylate overdose on lipopolysaccharide-induced lung injury in rats: the role of the VEGF
dc.typeArticle

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