Protective effect of curcumin on carbapenem-resistant Escherichia coli-induced lung injury in rats

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dc.contributor.authorBali, Çağla
dc.contributor.authorAltıntaş, Nejat
dc.contributor.authorÖzmete, Özlem
dc.contributor.authorGelincik, İbrahim
dc.contributor.authorYabanoğlu, Hakan
dc.contributor.authorTekin, Neslihan
dc.contributor.authorAltınsoy, Bülent
dc.contributor.authorTuran, Bünyamin Cüneyt
dc.contributor.authorArıboğan, Anıs
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:18:22Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:18:22Z
dc.date.issued2016
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractCurcumin has remarkable anti-inflammatory and antioxidant properties. The aim of this study was to investigate the protective effects of curcumin on a rat model of carbapenemresistant Escherichia coli-induced acute lung injury (ALI). Thirty-two rats were randomly allocated to 4 groups to induce an ALI: negative control group (rats not infected with E coli with no antibiotic treatment), positive control group (rats infected with E coli with no antibiotic treatment), imipenem group (rats infected with E coli that received intraperitoneal injection of imipenem), and the imipenem+curcumin group (rats infected with E coli that received intraperitoneal injection of imipenem and were fed on curcumin). The rats were killed, and lung tissues samples were harvested for biochemical analyses and histopathologic examination. Total antioxidant status (TAS), total oxidant status (TOS), tumor necrosis factor alpha (TNF alpha), and interleukin-6 (IL6) were measured. TOS increased in the positive control group (P < 0.001) and decreased in the imipenem and imipenem+curcumin groups (P < 0.001 and P < 0.001, respectively). TAS decreased in the positive control group (P = 0.005). Imipenem treatment did not increase TAS, but the imipenem+curcumin group increased TAS (P = 0.014). TNF alpha and IL6 increased in the positive control group compared with the negative control group (P < 0.001 and P = 0.010, respectively). Imipenem decreased TNF alpha (P < 0.001), but did not decrease IL6 (P = 0.418). Imipenem+curcumin decreased TNF alpha (P < 0.001); this decrease was more pronounced compared with the imipenem group (P = 0.008). IL6 decreased in the curcumin group compared with the positive control group (P = 0.011). Curcumin combined with imipenem can be an alternative therapeutic agent to overcome the resistance of E coli strains.
dc.description.sponsorshipBaskent University [DA 15/05]
dc.description.sponsorshipThis study was supported by the Baskent University Research Fund (Project DA 15/05).
dc.identifier.doi10.9738/INTSURG-D-15-00256.1
dc.identifier.endpage312en_US
dc.identifier.issn0020-8868
dc.identifier.issue07.Augen_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage304en_US
dc.identifier.urihttps://doi.org/10.9738/INTSURG-D-15-00256.1
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4870
dc.identifier.volume101en_US
dc.identifier.wosWOS:000406051800002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCollege of Surgeons
dc.relation.ispartofInternational Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCurcumin
dc.subjectCarbapenem-resistant E Coli
dc.subjectAcute Lung Injury
dc.titleProtective effect of curcumin on carbapenem-resistant Escherichia coli-induced lung injury in rats
dc.typeArticle

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