A generic platform for self-illuminating unimolecular systems enabling photodynamic therapy
| dc.contributor.author | Toksoy, Alihan | |
| dc.contributor.author | Pekcan, Simge | |
| dc.contributor.author | Susam, Alim | |
| dc.contributor.author | Erkan, Dilek Sadife | |
| dc.contributor.author | Algı, Melek Pamuk | |
| dc.contributor.author | Algı, Fatih | |
| dc.date.accessioned | 2023-09-27T10:29:33Z | |
| dc.date.available | 2023-09-27T10:29:33Z | |
| dc.date.issued | 2023 | |
| dc.department | Sabire Yazıcı Fen Edebiyat Fakültesi | |
| dc.description.abstract | This work delineates a generic platform, 1-((1,4-dioxo-1,2,3,4-tetrahydrophthalazin-6-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoate, (conjugate 1), for self-illuminating unimolecular systems that can both glow in physiological pH (7.4) and enable photodynamic therapy (PDT) in highly acidic environments. It is noteworthy that conjugate 1 induces chemiluminescence upon treatment with KO2 at physiological pH. Also, it is remarkable that this straightforward design effectively boosts the singlet oxygen generation. Most strikingly, conjugate 1 can function as a photosensitizer even in highly acidic environments. Crucially, conjugate 1 shows in vitro phototoxicity when illuminated for 30 min. Furthermore, the capability of conjugate 1 as a self-illuminating PDT agent is explored. To our delight, we noted that conjugate 1 can eliminate 79% of cancerous cells upon chemical excitation being triggered in vitro. The data render its efficiency as a self-illuminating anticancer therapy agent. Last but not least, conjugate 1 can successfully inhibit the growth of bacteria. Also, we found that the shelf life of the acidic beverages can be extended from 2 days to ? 6–7 days after photodynamic sterilization with conjugate 1. To our best knowledge, this is the first example of luminol-based self-illuminating unimolecular systems enabling PDT for anticancer and antibacterial activities. | |
| dc.identifier.doi | 10.1016/j.dyepig.2023.111577 | |
| dc.identifier.issn | 0143-7208 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | https:/dx.doi.org10.1016/j.dyepig.2023.111577 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/10981 | |
| dc.identifier.volume | 219 | en_US |
| dc.identifier.wos | WOS:001052359900001 | |
| dc.identifier.wosquality | Q1 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | |
| dc.publisher | Elsevier Ltd | |
| dc.relation.ispartof | Dyes and Pigments | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | Chemiluminescence | |
| dc.subject | In Vitro Imaging | |
| dc.subject | Methicillin-resistant Staphylococcus aureus (MRSA) | |
| dc.subject | Photodynamic Therapy | |
| dc.subject | Photodynamic Sterilization | |
| dc.title | A generic platform for self-illuminating unimolecular systems enabling photodynamic therapy | |
| dc.type | Article |
