Increased micronucleus, nucleoplasmic bridge, nuclear bud frequency and oxidative DNA damage associated with prolactin levels and pituitary adenoma diameters in patients with prolactinoma

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dc.authoridDonmez Altuntas, Hamiyet -- 0000-0001-6473-5813
dc.contributor.authorBitgen, Nazmiye
dc.contributor.authorDönmez-Altuntaş, H.
dc.contributor.authorBayram, F.
dc.contributor.authorÇakIr, I.
dc.contributor.authorHamurcu, Z.
dc.contributor.authorDiri, H.
dc.contributor.authorBaşkol, G.
dc.contributor.authorŞenol, S.
dc.contributor.authorDurak, A. C.
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:29:24Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:29:24Z
dc.date.issued2016
dc.departmentAksaray Teknik Bilimler Meslek Yüksekokulu
dc.description.abstractProlactinoma is the most common pituitary tumor. Most pituitary tumors are benign, but they often are clinically significant. We investigated cytokinesis-block micronucleus cytome (CBMN cyt) assay parameters and oxidative DNA damage in patients with prolactinoma to assess the relations among age, prolactin level, pituitary adenoma diameter and 8-hydroxy-2'-deoxyguanosine (8-OHdG) level in patients with prolactinoma. We investigated 27 patients diagnosed with prolactinoma and 20 age- and sex-matched healthy controls. We measured CBMN cyt parameters and plasma 8-OHdG levels in peripheral blood lymphocytes of patients with prolactinoma and controls. The frequencies of micronucleus (MN), nucleoplasmic bridge, nuclear bud, apoptotic and necrotic cells, and plasma 8-OHdG levels in patients with prolactinoma were significantly greater than controls. MN frequency was correlated positively with age, prolactin levels and pituitary adenoma diameters in patients with prolactinoma. The increased chromosomal and oxidative DNA damage, and the positive correlation between MN frequency, prolactin levels and pituitary adenoma diameters may be associated with increased risk of cancer in patients with prolactinoma, because increased MN frequency is a predictor of cancer risk.
dc.description.sponsorshipErciyes University Scientific Research Projects Units [TSD-10-3327]
dc.description.sponsorshipThis work was supported by Erciyes University Scientific Research Projects Units (Project number: TSD-10-3327). N. B., H. D-A., F. B., I. C., Z. H., H. D., G. B., S. S. and A. C. D. designed and performed the experiments; N. B., H. D-A. and F. B. analyzed data and wrote the paper.
dc.identifier.doi10.3109/10520295.2015.1101163
dc.identifier.endpage136en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2en_US
dc.identifier.pmid26720589
dc.identifier.scopusqualityQ2
dc.identifier.startpage128en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2015.1101163
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6164
dc.identifier.volume91en_US
dc.identifier.wosWOS:000368552800008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofBiotechnic and Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subject8-OHdG
dc.subjectApoptosis
dc.subjectCBMN Cyt Assay
dc.subjectCytokinesis-Block Micronucleus Cytome
dc.subjectNuclear Bud
dc.subjectMicronucleus
dc.subjectNucleoplasmic Bridge
dc.subjectProlactin
dc.subjectProlactinoma
dc.titleIncreased micronucleus, nucleoplasmic bridge, nuclear bud frequency and oxidative DNA damage associated with prolactin levels and pituitary adenoma diameters in patients with prolactinoma
dc.typeArticle

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