Plasma polymerization-modified bacterial polyhydroxybutyrate nanofibrillar scaffolds

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dc.authoridSAM, Mesut -- 0000-0002-6429-7144; SAGLAM, NECDET -- 0000-0002-5463-8355
dc.contributor.authorKarahaliloğlu, Zeynep
dc.contributor.authorDemirbilek, Murat
dc.contributor.authorŞam, Mesut
dc.contributor.authorErol-Demirbilek, Melike
dc.contributor.authorSağlam, Necdet
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:27:29Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:27:29Z
dc.date.issued2013
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThe design and the development of novel scaffold materials for tissue engineering have attracted much interest in recent years. Especially, the prepared nanofibrillar scaffold materials from biocompatible and biodegradable polymers by electrospinning are promising materials to be used in biomedical applications. In this study, we propose to produce low-cost and cell-friendly bacterial electrospun PHB polymeric scaffolds by using Alcaligenes eutrophus DSM 545 strain to PHB production. The produced PHB was characterized by Nuclear Magnetic Resonance (NMR) and Fourier Transform Infrared Spectroscopy (FTIR). Nanofibrous scaffolds were fabricated via electrospinning method that has a fiber diameter approximately 700800 nm. To investigate cell attachment, cell growth, and antioxidant enzyme activity on positively and negatively charged PHB scaffold, PHB surface was modified by plasma polymerization technique using polyethylene glycol (PEG) and ethylenediamine (EDA). According to the results of superoxide dismutase (SOD) activity study, PEG-modified nanofibrillar scaffolds indicated more cellular resistance against oxidative stress compared to the EDA modification. As can be seen in cell proliferation results, EDA modification enhanced the cell proliferation more than PEG modification, while PEG modification is better as compared with nonmodified scaffolds. In general, through plasma polymerization technique, surface modified nanofibrillar structures are effective substrates for cell attachment and outgrowth. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
dc.description.sponsorshipHacettepe University, Scientific Researches Unit
dc.description.sponsorshipThis study was carried out under the auspices of the Hacettepe University, Scientific Researches Unit. The authors would like to thank Koray Mizrak and Cem Bayram for their help in SEM and XPS characterizations.
dc.identifier.doi10.1002/app.38370
dc.identifier.endpage1912en_US
dc.identifier.issn0021-8995
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage1904en_US
dc.identifier.urihttps://doi.org/10.1002/app.38370
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5874
dc.identifier.volume128en_US
dc.identifier.wosWOS:000314927200069
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiocompatibility
dc.subjectBiopolymers and Renewable Polymers
dc.subjectPolyesters
dc.subjectNanofiber
dc.titlePlasma polymerization-modified bacterial polyhydroxybutyrate nanofibrillar scaffolds
dc.typeArticle

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