Multi-stimuli-responsive carboxymethyl cellulose/κ-carrageenan nanogels integrated with magnetic graphene oxide for colon-specific delivery of sunitinib
| dc.contributor.author | Işıklan, Nuran | |
| dc.contributor.author | Aytekin, Harun | |
| dc.contributor.author | Sonkaya, Ömer | |
| dc.contributor.author | Güncüm, Enes | |
| dc.date.accessioned | 2025-07-18T11:09:16Z | |
| dc.date.available | 2025-07-18T11:09:16Z | |
| dc.date.issued | 2025 | |
| dc.department | Teknik Bilimler Meslek Yüksekokulu | |
| dc.description.abstract | The multi-stimuli-responsive nanohydrogels provide a powerful strategy for enhancing drug utilization, preservation, controlled release, and minimizing systemic toxicity. Herein, we designed and developed a new multi-stimuli-responsive magnetic graphene oxide (MGO) integrated carboxymethyl cellulose/κ-carrageenan (CMC/CG/MGO) nanogels (NGs) for colon-specific delivery of sunitinib (SU). The physicochemical properties of the CMC/CG/MGO NGs were investigated by various analytical techniques of XRD, FTIR, TGA VSM, DLS, BET, and FESEM/TEM. The in-vitro SU release results exhibited that the CMC/CG/MGO NGs have a sustained release behavior with good pH, magnetic field, and near-infrared (NIR) light-dependent properties. The integrated photothermal agent MGO endowed the CMC/CG NGs with efficient photothermal properties, enabling precise SU release control under NIR laser irradiation. The CMC/CG/MGO/SU NGs displayed a good photothermal conversion effect (η = 38.5%). Besides, the CMC/CG/MGO NGs were not cytotoxic (cell viability > 73% at 15.6–500 ppm) for the L929 fibroblast and Caco-2 cell lines. The MTT results also revealed that the CMC/CG/MGO/SU NGs exhibited enhanced anti-cancer activity compared to free SU under NIR laser irradiation. These results highlight the potential of CMC/CG/MGO/SU NGs as a promising candidate for remotely controlled multi-stimuli-responsive drug delivery. | |
| dc.identifier.doi | 10.1007/s10570-025-06635-3 | |
| dc.identifier.issn | 09690239 | |
| dc.identifier.scopus | 105009711539 | |
| dc.identifier.uri | https://dx.doi.org/10.1007/s10570-025-06635-3 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/13382 | |
| dc.identifier.wos | WOS:001524827200001 | |
| dc.identifier.wosquality | Q1 | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | Web of Science | |
| dc.institutionauthor | Sonkaya, Ömer | |
| dc.language.iso | en | |
| dc.publisher | Springer Science and Business Media B.V. | |
| dc.relation.ispartof | Cellulose | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Carboxymethyl Cellulose | |
| dc.subject | Magnetic Graphene Oxide | |
| dc.subject | Multi-stimuli-responsive Hydrogels | |
| dc.subject | Sunitinib | |
| dc.subject | κ-carrageenan | |
| dc.title | Multi-stimuli-responsive carboxymethyl cellulose/κ-carrageenan nanogels integrated with magnetic graphene oxide for colon-specific delivery of sunitinib | |
| dc.type | Article |
