Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder
| dc.contributor.author | Çetinkaya, Miray | |
| dc.contributor.author | Kara, Halil | |
| dc.contributor.author | Açıkel, Burak | |
| dc.contributor.author | Tuncer, Sibel Çigdem | |
| dc.date.accessioned | 2022-09-05T06:46:56Z | |
| dc.date.available | 2022-09-05T06:46:56Z | |
| dc.date.issued | 2022 | |
| dc.department | Tıp Fakültesi | |
| dc.description.abstract | It has been recently emphasized that neurodevelopmental disorders such as schizophrenia, autism spectrum disorder and attention deficit hyperactivity disorder (ADHD) may be related to the gut-brain axis. Zonulin is a protein that changes the integrity of tight junctions between gastrointestinal mucosa cells. We aimed to investigate serum zonulin levels and its relationship with symptom severity in children with ADHD. Method: 21 ADHD patients and 19 controls were included. Zonulin levels were obtained from blood specimens. Clinical severity of the ADHD symptoms was evaluated by Conner’s Parents Rating Scale-Revised/Long Form (CPRS-R/L) and Conner’s Teacher Rating Scale-Revised/Long Form (CTRS-R/L) in ADHD group. Results: There was no significant difference between the groups in terms of age, gender and body mass index. Mean serum zonulin level of the ADHD group was 13.45±9.08 and 21.32± 19.96 in the control group. There was no significant difference between groups (t=1.99, p=0.51). Significant correlation was found (R=0.82, p<0.01) between serum zonulin levels and CTRS-R/L scores in the ADHD group. This correlation persisted when BMI and sex variables were controlled (R=0.85, p<0.01). Discussion: We have found significant correlation between ADHD symptom severity and serum zonulin levels, whereas there was no significant difference between children with ADHD and controls. | |
| dc.identifier.doi | 10.5505/kpd.2022.74317 | |
| dc.identifier.endpage | 147 | en_US |
| dc.identifier.issn | 1302-0099 | |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.scopusquality | Q4 | |
| dc.identifier.startpage | 140 | en_US |
| dc.identifier.uri | https:/dx.doi.org/10.5505/kpd.2022.74317 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/9666 | |
| dc.identifier.volume | 25 | en_US |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.language.iso | en | |
| dc.publisher | ANP Publishing | |
| dc.relation.ispartof | Klinik Psikiyatri Dergisi | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Attention Deficit | |
| dc.subject | Children | |
| dc.subject | Gut | |
| dc.subject | Intestinal | |
| dc.subject | Zonulin | |
| dc.title | Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder | |
| dc.title.alternative | Dikkat eksikliği hiperaktivite bozukluğu olan çocuklarda serum zonulin seviyelerinin belirti şiddeti, vücut kitle indeksi ve cinsiyet ile ilişkisi | |
| dc.type | Article |
