Comprehensive assessment of phytochemical profile and biological activity of local endemic species Kalidium wagenitzii extracts

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dc.authorid0000-0002-1285-659X
dc.authorid0000-0001-6548-7823
dc.authorid0000-0001-8954-5485
dc.contributor.authorŞen, İsmail
dc.contributor.authorZengin, Gökhan
dc.contributor.authorÇakmak, Yavuz Selim
dc.date.accessioned2025-07-18T12:56:06Z
dc.date.available2025-07-18T12:56:06Z
dc.date.issued2025
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractPlant bioactive compounds are promising natural alternatives to synthetic drugs due to their important biological activities. These phytochemicals are involved in plant metabolism and serve as adaptive responses to environmental changes. Especially, plants that grow under extreme environmental conditions often have unique phytochemical profiles and strong biological effects. This study focused on the biological activities of different extracts from Kalidium wagenitzii, a rare species of the Amaranthaceae family endemic to the Salt Lake basin in Aksaray, Turkey. Due to its limited habitat, the plant is thought to possess a distinctive phytochemical composition. Antioxidant activities were assessed using DPPH, ABTS, CUPRAC, FRAP, PBD, and MCA assays, along with total phenolic and flavonoid content analysis. Enzyme inhibitory activities were evaluated for cholinesterases, α-amylase, α-glucosidase, and tyrosinase. Aqueous extract showed strong acetylcholinesterase (0.31 ± 0.02 mg GALAE/g) and tyrosinase (29.82 ± 0.92 mg KAE/g) inhibition. Methanolic extract was most effective against butyrylcholinesterase (1.93 ± 0.16 mg GALAE/g), while ethyl acetate extract had the highest α-amylase (308.51 ± 0.58 mg ACAE/g) and α-glucosidase (498.30 ± 3.07 mg ACAE/g) inhibition. HPLC analysis revealed epicatechin in ethyl acetate, catechin in methanol, and both in aqueous extract. These results suggest that K. wagenitzii has strong therapeutic potential, especially in managing diabetes.
dc.identifier.doi10.1080/11263504.2025.2489997
dc.identifier.endpage615
dc.identifier.issn11263504
dc.identifier.issue3
dc.identifier.scopus105003236436
dc.identifier.startpage606
dc.identifier.urihttps://dx.doi.org/10.1080/11263504.2025.2489997
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13390
dc.identifier.volume159
dc.identifier.wosWOS:001471230000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorŞen, İsmail
dc.institutionauthorid0000-0002-1285-659X
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofPlant Biosystems
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntidiabetic Activity
dc.subjectAntioxidant
dc.subjectBiochemistry
dc.subjectEnzyme Inhibition
dc.subjectPharmacology
dc.titleComprehensive assessment of phytochemical profile and biological activity of local endemic species Kalidium wagenitzii extracts
dc.typeArticle

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