Ameliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways

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dc.contributor.authorŞimşek, Hasan
dc.contributor.authorAkaras, Nurhan
dc.contributor.authorGür, Cihan
dc.contributor.authorKüçükler, Sefa
dc.contributor.authorİleritürk, Mustafa
dc.contributor.authorKandemir, Fatih Mehmet
dc.date.accessioned2025-07-11T08:10:34Z
dc.date.available2025-07-11T08:10:34Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractDiclofenac (Diclo) is a therapeutic agent used in the treatment of pain and inflammatory diseases, but it is also toxic to the human body. Morin is a flavonoid found naturally in plants and has many biological and pharmacological activities, including anti-inflammatory, anti-oxidant, and anticancer activities. This study aimed to investigate the efficacy of Morin in Diclo-induced testicular toxicity. Materials and Methods: Morin (50 mg/kg and 100 mg/kg) was administered orally for five days, while Diclo was administered intraperitoneally at 50 mg/kg on days 4 and 5. Biochemical, molecular, and histological methods were used to investigate oxidative stress, inflammation, apoptosis, and endoplasmic reticulum (ER) stress damage indicators in testicular tissue. Results: Morin treatment attenuated Diclo-induced oxidative stress damage by increasing anti-oxidant levels (SOD, CAT, GPx, GSH, Nrf-2, HO-1, and NQO1) and decreasing MDA levels, an indicator of lipid peroxidation. Morin reduced levels of the inflammatory mediators NF-κB protein. Increases in apoptotic Bax and Caspase-3 by Diclo were reduced by Morin, while decreased antiapoptotic Bcl-2 level was increased. Morin reduced Diclo-induced ER stress injury by decreasing ATF-6, PERK, IRE1, GRP-78, and CHOP levels. Also, Diclo decreased COX-2 levels. Conclusion: Overall, Morin may be an effective treatment of choice for testicular tissue damage associated with Diclo toxicity and may reduce the level of damage.
dc.identifier.doi10.22038/IJBMS.2025.79735.17270
dc.identifier.endpage515
dc.identifier.issn20083866
dc.identifier.issue4
dc.identifier.scopus85216993646
dc.identifier.startpage507
dc.identifier.urihttps://dx.doi.org/10.22038/IJBMS.2025.79735.17270
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13259
dc.identifier.volume28
dc.identifier.wosWOS:001417648600013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorŞimşek, Hasan
dc.institutionauthorAkaras, Nurhan
dc.institutionauthorKandemir, Fatih Mehmet
dc.language.isoen
dc.publisherMashhad University of Medical Sciences
dc.relation.ispartofIranian Journal of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectDiclofenac
dc.subjectEndoplasmic Reticulum - Stress
dc.subjectInflammation
dc.subjectMorin
dc.subjectOxidative Stress
dc.titleAmeliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways
dc.typeArticle

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