Ameliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways
dc.contributor.author | Şimşek, Hasan | |
dc.contributor.author | Akaras, Nurhan | |
dc.contributor.author | Gür, Cihan | |
dc.contributor.author | Küçükler, Sefa | |
dc.contributor.author | İleritürk, Mustafa | |
dc.contributor.author | Kandemir, Fatih Mehmet | |
dc.date.accessioned | 2025-07-11T08:10:34Z | |
dc.date.available | 2025-07-11T08:10:34Z | |
dc.date.issued | 2025 | |
dc.department | Tıp Fakültesi | |
dc.description.abstract | Diclofenac (Diclo) is a therapeutic agent used in the treatment of pain and inflammatory diseases, but it is also toxic to the human body. Morin is a flavonoid found naturally in plants and has many biological and pharmacological activities, including anti-inflammatory, anti-oxidant, and anticancer activities. This study aimed to investigate the efficacy of Morin in Diclo-induced testicular toxicity. Materials and Methods: Morin (50 mg/kg and 100 mg/kg) was administered orally for five days, while Diclo was administered intraperitoneally at 50 mg/kg on days 4 and 5. Biochemical, molecular, and histological methods were used to investigate oxidative stress, inflammation, apoptosis, and endoplasmic reticulum (ER) stress damage indicators in testicular tissue. Results: Morin treatment attenuated Diclo-induced oxidative stress damage by increasing anti-oxidant levels (SOD, CAT, GPx, GSH, Nrf-2, HO-1, and NQO1) and decreasing MDA levels, an indicator of lipid peroxidation. Morin reduced levels of the inflammatory mediators NF-κB protein. Increases in apoptotic Bax and Caspase-3 by Diclo were reduced by Morin, while decreased antiapoptotic Bcl-2 level was increased. Morin reduced Diclo-induced ER stress injury by decreasing ATF-6, PERK, IRE1, GRP-78, and CHOP levels. Also, Diclo decreased COX-2 levels. Conclusion: Overall, Morin may be an effective treatment of choice for testicular tissue damage associated with Diclo toxicity and may reduce the level of damage. | |
dc.identifier.doi | 10.22038/IJBMS.2025.79735.17270 | |
dc.identifier.endpage | 515 | |
dc.identifier.issn | 20083866 | |
dc.identifier.issue | 4 | |
dc.identifier.scopus | 85216993646 | |
dc.identifier.startpage | 507 | |
dc.identifier.uri | https://dx.doi.org/10.22038/IJBMS.2025.79735.17270 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12451/13259 | |
dc.identifier.volume | 28 | |
dc.identifier.wos | WOS:001417648600013 | |
dc.identifier.wosquality | Q3 | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | Web of Science | |
dc.institutionauthor | Şimşek, Hasan | |
dc.institutionauthor | Akaras, Nurhan | |
dc.institutionauthor | Kandemir, Fatih Mehmet | |
dc.language.iso | en | |
dc.publisher | Mashhad University of Medical Sciences | |
dc.relation.ispartof | Iranian Journal of Basic Medical Sciences | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Apoptosis | |
dc.subject | Diclofenac | |
dc.subject | Endoplasmic Reticulum - Stress | |
dc.subject | Inflammation | |
dc.subject | Morin | |
dc.subject | Oxidative Stress | |
dc.title | Ameliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways | |
dc.type | Article |