Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients
| dc.authorid | 0000-0003-1975-6492 | |
| dc.authorid | 0000-0003-0840-2613 | |
| dc.authorid | 0000-0002-4030-1145 | |
| dc.contributor.author | Kurt, Fatih | |
| dc.contributor.author | Eröz, Recep | |
| dc.contributor.author | Kocabay, Kenan | |
| dc.date.accessioned | 2024-03-12T13:09:42Z | |
| dc.date.available | 2024-03-12T13:09:42Z | |
| dc.date.issued | 2023 | |
| dc.department | Tıp Fakültesi | |
| dc.description.abstract | This study was carried out to compare the expression levels of ASC(Apoptosis Associated Speck Like Protein Containing a CARD), TL-1a(TNF Like Factor 1a) and CXCL 13(B Cell Chemoattractant Chemokine Ligand 13) genes in FMF patients According to Tell-Hashomer Criteria and Genetic analysis result in Düzce University Research and Application Hospital with healthy controls and to determine their clinical significance in FMF. Method: 36 patients (20 girls, 16 boys) and 12 healthy controls (7 girls, 5 boys) were included in the study. RNA was isolated from the peripheral blood of each individual and expression levels of ASC, TL-1a and CXCL 13 genes were determined. Routine biochemical parameters were also determined. Result: CXCL 13 and TL-1a gene expression levels were significantly increased in patients with FMF, the expression level of the ASC gene was found to be increased in FMF patients, but not significantly. Conclusion: The expression levels of these genes may be related to the pathogenesis of the disease and these genes could be used as a marker in the early diagnosis of the disease. | |
| dc.description.abstract | Bu çalışma genetik analizi Düzce Üniversitesi Araştırma ve Uygulama Hastanesi'nde yapılan ve Tell-Hashomer Kriterleri’ne göre Ailesel Akdeniz Ateşi tanısı konan hastalarda ASC (Apoptosis Associated Speck Like Protein Containing a CARD), TL-1a(TNF Like Factor 1a) ve CXCL 13(B Cell Chemoatractant Chemokine Ligand 13) genlerinin ekspresyon düzeylerini sağlıklı kontroller ile karşılaştırmak ve AAA'daki klinik önemini belirlemek amacıyla yapılmıştır. Metod: Çalışmaya 36 hasta (20 kız, 16 erkek) ve 12 sağlıklı kontrol (7 kız, 5 erkek) dahil edildi. Her bireyin periferik kanından RNA izole edildi ve ASC, TL-1a ve CXCL 13 genlerinin ekspresyon seviyeleri belirlendi. Rutin biyokimyasal parametreler de belirlendi. Bulgular: AAA hastalarında CXCL 13 ve TL-1a gen ekspresyon seviyeleri anlamlı olarak artarken, ASC geninin ekspresyon seviyesinin arttığı ancak anlamlı olmadığı bulundu. Sonuç: Bu genlerin ekspresyon düzeyleri hastalığın patogenezi ile ilişkili olabilir ve bu genler hastalığın erken tanısında bir belirteç olarak kullanılabilir. | |
| dc.identifier.doi | 10.18521/ktd.1162175 | |
| dc.identifier.endpage | 68 | en_US |
| dc.identifier.issn | 1309-3878 | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.startpage | 59 | en_US |
| dc.identifier.uri | https:/dx.doi.org10.18521/ktd.1162175 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/11460 | |
| dc.identifier.volume | 15 | en_US |
| dc.identifier.wosquality | N/A | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.language.iso | en | |
| dc.publisher | Düzce Üniversitesi | |
| dc.relation.ispartof | Konuralp Tıp Dergisi | |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | FMF | |
| dc.subject | ASC | |
| dc.subject | CXCL13 | |
| dc.subject | TL-1a | |
| dc.subject | AAA | |
| dc.title | Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients | |
| dc.title.alternative | Ailesel Akdeniz Ateşi (AAA) Hastalarında Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) ve B Cell Chemoattractant Chemokine Ligand 13(CXCL 13) Genlerinin Ekpresyon Düzeylerinin İncelenmesi | |
| dc.type | Article |
