Antidiabetic effects and enzymatic antioxidant activity of chicken drumstick mushroom (Coprinus comatus) extract in diabetic rats model

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dc.authorid0000-0002-1521-3100
dc.authorid0000-0001-6785-7832
dc.authorid0000-0002-1938-6260
dc.authorid0000-0001-9641-9321
dc.authorid0000-0003-3278-4711
dc.authorid0000-0002-7841-1999
dc.contributor.authorRatnaningtyas, Nuniek Ina
dc.contributor.authorHusen, Fajar
dc.contributor.authorSukmawati, Dalia
dc.contributor.authorWibowo, Eko Setio
dc.contributor.authorHikam, Arif Rahman
dc.contributor.authorAksoy, Adil
dc.date.accessioned2023-01-10T06:00:01Z
dc.date.available2023-01-10T06:00:01Z
dc.date.issued2022
dc.departmentEskil Meslek Yüksekokulu
dc.description.abstractCoprinus comatus (O.F. Mull.) Pers. is a medicinal and edible mushroom containing bioactive compounds known as antidiabetic and antioxidant agents. The pancreatic ?-cells were sensitive to reactive oxygen species (ROS) attacks, which can cause necrosis and disrupt insulin production. Therefore, this research aimed to evaluate the C. comatus ethyl acetate extract for antidiabetic and antioxidant to decrease fasting blood glucose, dipeptidyl peptidase-4 enzyme (DPP-4) levels, and increase glutathione peroxidase (GPx). Subsequently, 24 male Wistar rats were divided into six groups, namely 2-5 streptozotocin (STZ)-induced 45 mg/kg, 1/HC (without any treatment), 2/NC (negative control), 3/PC (administered metformin 45 mg/kg Body weight (BW), 4-6 (T1: administered 250 mg, T2: administered 500 mg, and T3: administered 750 mg/kg BW extract). The parameters were analyzed using ANOVA, followed by Duncan’s multiple range test. According to the results, the extract significantly decreased DPP-4 levels, blood glucose and increased GPx (p ? 0.05). The 500 mg extract effectively reduced blood glucose levels and DPP-4 enzyme as well as increased levels of GPx.
dc.identifier.doi10.22207/JPAM.16.4.48
dc.identifier.endpage2774en_US
dc.identifier.issn0973-7510
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage2764en_US
dc.identifier.urihttps:/dx.doi.org/10.22207/JPAM.16.4.48
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9850
dc.identifier.volume16en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherJournal of Pure and Applied Microbiology
dc.relation.ispartofJournal of Pure and Applied Microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntidiabetic
dc.subjectCoprinus Comatus
dc.subjectEnzymatic Antioxidant
dc.subjectMedicinal Mushroom
dc.subjectReactive Oxygen Species
dc.titleAntidiabetic effects and enzymatic antioxidant activity of chicken drumstick mushroom (Coprinus comatus) extract in diabetic rats model
dc.typeArticle

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