Effects of S-allyl cysteine on lung and liver tissue in a rat model of lipopolysaccharide-induced sepsis

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dc.contributor.authorBayraktar, Orhan
dc.contributor.authorTekin, Neslihan
dc.contributor.authorAydın, Özlem
dc.contributor.authorAkyüz, Fahrettin
dc.contributor.authorMusmul, Ahmet
dc.contributor.authorBurukoğlu, Dilek
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:27:14Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:27:14Z
dc.date.issued2015
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractSepsis is characterized by a severe production of reactive oxygen species (ROS) and other radical species with consequent oxidative stress. S-allyl cysteine (SAC) is a water-soluble organosulfur component present in garlic which is a potent antioxidant and free radical scavenger. In the present study, the purpose was to explore the anti-inflammatory, antioxidant, and anti-apoptotic actions of SAC on lipopolysaccharide (LPS)-induced sepsis in rats. Thirty-two male Wistar rats were separated into 4 groups. These were control, SAC control, sepsis, and sepsis + SAC-induced groups. Sepsis was induced by administration of LPS (5 mg/kg) into 2 groups. SAC (50 mg/kg) was given orally to SAC control and SAC treatment groups per 12 h during 2 days after intraperitoneal LPS injection. Serum AST, ALT, ALP, and hsCRP levels and liver and lung MPO, NO, and DNA fragmentation levels were evaluated. In sepsis group, elevated levels of ALT, AST, ALP, and hsCRP were observed. The abnormal increases were decreased in sepsis + SAC group compared to sepsis group. In lung tissue, MPO and NO levels were increased in sepsis group compared to the control group. MPO activity and NO levels were decreased by SAC application in sepsis + SAC group compared with sepsis group. In liver tissue, DNA fragmentation was significantly higher in sepsis group than that in the control group. In contrast, a decreased level of DNA fragmentation was noted in sepsis + SAC group when compared with the sepsis group. In conclusion, SAC ameliorates LPS-induced indicators of liver damage and suppresses the discharge of NO and MPO in lung tissue via its antioxidant properties.
dc.identifier.doi10.1007/s00210-014-1076-z
dc.identifier.endpage335en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue3en_US
dc.identifier.pmid25480742
dc.identifier.scopusqualityQ2
dc.identifier.startpage327en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-014-1076-z
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5820
dc.identifier.volume388en_US
dc.identifier.wosWOS:000350311800006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLipopolysaccharide
dc.subjectS-allyl Cysteine
dc.subjectNitric Oxide
dc.subjectDNA Fragmentation
dc.subjectAntioxidant
dc.titleEffects of S-allyl cysteine on lung and liver tissue in a rat model of lipopolysaccharide-induced sepsis
dc.typeArticle

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