Synthesis, structural characterization and DNA interaction of zinc complex from 2,6-diacetylpyridine dihydrazone and {4-[(2E)-2-(hydroxyimino)acetyl]phenoxy} acetic acid

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dc.authoridOzcelik, Nefise -- 0000-0002-6972-1071; Gokce, Cansu -- 0000-0002-6834-4841
dc.contributor.authorGüp, Ramazan
dc.contributor.authorGökçe, Cansu
dc.contributor.authorDilek, Nefise
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:28:56Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:28:56Z
dc.date.issued2015
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractA new water soluble zinc complex has been prepared and structurally characterized. The Zn(II) complex was synthesized by the reaction of 2,6-diacetylpyridine dihydrazone (dph) with {4-[(2E)-2-(hydroxyimino) acetyl]phenoxy} acetic acid (H2L) in the presence of zinc(II) acetate. Single crystal X-ray diffraction study revealed that the zinc ion is situated in distorted trigonal-bipyramidal environment where the equatorial position is occupied by the nitrogen atom of pyridine ring and the oxygen atoms of acetate groups of two oxime ligands (H2L) whereas the axial positions of the zinc complex are occupied by the imine nitrogen atoms of dph ligand. Characterization of the complex with FTIR, H-1 and C-13 NMR, UV-vis and elemental analysis also confirmed the proposed structure. Interaction of the Zn(II) complex with calf-thymus DNA (CT-DNA) was investigated through UV-vis spectroscopy and viscosity measurements. The results suggest that the complex preferably bind to DNA through the groove binding mode. The zinc complex cleaves plasmid pBR 322 DNA in the presence and absence of an oxidative agent (H2O2), possibly through a hydrolytic pathway which is also supported by DNA cleave experiments in the presence of different radical scavengers. The nuclease activity of the zinc complex significantly depends on concentration of the complex and incubation time both in the presence and absence of H2O2. DNA cleave activity is inhibited in the presence of methyl green indicating that the zinc complex seems to bind the major groove of DNA. (C) 2015 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey - Turkey (TUBITAK) [TBAG-112T315]; Aksaray University, Science and Technology Application and Research Center, Turkey (State of Planning Organization) [2010K120480]
dc.description.sponsorshipThis work was funded by the Scientific and Technological Research Council of Turkey - Turkey (TUBITAK, TBAG-112T315). The authors acknowledge the Aksaray University, Science and Technology Application and Research Center, Turkey, for the use of the Bruker Smart Breeze CCD diffractometer (purchased under-grant 2010K120480 of the State of Planning Organization).
dc.identifier.doi10.1016/j.jphotobiol.2015.02.002
dc.identifier.endpage50en_US
dc.identifier.issn1011-1344
dc.identifier.pmid25704313
dc.identifier.scopusqualityQ1
dc.identifier.startpage42en_US
dc.identifier.urihttps://doi.org/10.1016/j.jphotobiol.2015.02.002
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6106
dc.identifier.volume144en_US
dc.identifier.wosWOS:000351800900007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofJournal of Photochemistry and Photobiology B-Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.titleSynthesis, structural characterization and DNA interaction of zinc complex from 2,6-diacetylpyridine dihydrazone and {4-[(2E)-2-(hydroxyimino)acetyl]phenoxy} acetic acid
dc.typeArticle

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