Milk thistle may induce apoptosis in development of carbontetrachloride-induced liver DNA damage in rats
| dc.contributor.author | Aslan, Abdullah | |
| dc.contributor.author | Can, Muhammed İsmail | |
| dc.contributor.author | Kulo?lu, Tuncay | |
| dc.contributor.author | Başpınar, Serpil | |
| dc.date.accessioned | 13.07.201910:50:10 | |
| dc.date.accessioned | 2019-07-16T08:22:00Z | |
| dc.date.available | 13.07.201910:50:10 | |
| dc.date.available | 2019-07-16T08:22:00Z | |
| dc.date.issued | 2016 | |
| dc.department | Sabire Yazıcı Fen Edebiyat Fakültesi | |
| dc.description.abstract | The leaf and flower extracts of Slybum marianum [Milk thistle (MT)] have been used for liver, gall bladder and spleen disorders for centuries. 28 male Wistar albino (n=28, 8 weeks old) rats used in the study. The rats divided into 4 groups according to their live weights. The groups were: (i) Negative Control (NC): Normal water consuming group to which no CCl4 and MT is administered; (ii) Positive Control (PC): Normal water consuming group to which no CCl4 is administered but MT is administered; (iii) CCl4 Group: Normal water consuming and group to which CCl4 is administered (2 ml/kg live weight, ip); CCl4+MT group: CCl4 and MT administered group (2 ml/kg live weight, ip). Tissue apoptotic index was examined via TUNEL method. MDA determination in plasma tissue was carried out using a spectrophotometer. As a Results, MDA amount decreased in the CCl4+MT group (3,65 ± 0,15 nmol/ml) in comparison to CCl4 group (4,25 ± 0,21 nmol/ml) whereas it was observed in the CCl4+MT group (12,62 ± 0,91 %) that the apoptotic index (TUNEL results) decreases in comparison with the CCl4 group (22,62 ± 0,91 %) thus approaching normal values. These results show that MT plant has a protective effect on liver. © Mattioli 1885. | |
| dc.identifier.endpage | 151 | en_US |
| dc.identifier.issn | 1129-8723 | |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 146 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/2431 | |
| dc.identifier.volume | 18 | en_US |
| dc.identifier.wosquality | N/A | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | |
| dc.publisher | Mattioli 1885 S.p.A. | |
| dc.relation.ispartof | Progress in Nutrition | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | CCl4 | |
| dc.subject | DNA Damage | |
| dc.subject | Liver Damage | |
| dc.subject | Milk Thistle | |
| dc.subject | TUNEL | |
| dc.title | Milk thistle may induce apoptosis in development of carbontetrachloride-induced liver DNA damage in rats | |
| dc.type | Article |
