Resveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits

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dc.authoridPEKTAS, MEHMET BILGEHAN -- 0000-0001-9790-8397; Akar, Fatma -- 0000-0002-5432-0304; SURUCU, HUSEYIN SELCUK -- 0000-0002-9244-4236
dc.contributor.authorAkar, Fatma
dc.contributor.authorPektaş, Mehmet Bilgehan
dc.contributor.authorTufan, Can
dc.contributor.authorSöylemez, Selen
dc.contributor.authorSepici, Aylin
dc.contributor.authorUlus, Ahmet Tulga
dc.contributor.authorGökalp, Burcu
dc.contributor.authorÖztürk, Kamile
dc.contributor.authorSürücü, Hüseyin Selçuk
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:26:23Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:26:23Z
dc.date.issued2011
dc.departmentFen-Edebiyat Fakültesi
dc.description.abstractResveratrol has been shown to have vasoprotective effects by upregulating oxidative defense mechanisms in a variety of pathophysiological conditions. However, the effect of resveratrol on diabetic oxidative stress and vascular and metabolic abnormalities is not completely understood. Therefore, this study was designed to evaluate whether long-term resveratrol supplementation has a protective effect on vascular function and integrity in association with metabolic parameters and oxidative stress in insulin-dependent diabetes. Diabetes was induced in rabbits with alloxan and maintained for 8 weeks. We used a resveratrol dose of 5 mg/L (10 weeks, starting 14 days before alloxan injection) and 50 mg/L (8 or 10 weeks, starting concomitantly or 14 days before alloxan injection) in the drinking water of rabbits. Relaxation to acetylcholine was impaired (control 75.6 +/- 3.59%, versus diabetic 42.23 +/- 2.53%) and contractions to phenylephrine increased (control 136.89 +/- 2.27%, versus diabetic 159.37 +/- 6.27%) in aortas from diabetic animals. These changes were associated with increased basal or NAD(P)H-induced superoxide production, as well as lipid peroxide and superoxide dismutase (SOD) levels in the aortic samples. The maximal relaxation to acetylcholine improved by 75.74 +/- 9.04% in diabetic rabbits treated with resveratrol. The increased contractions to phenylephrine were not restored to control values after resveratrol treatments, but sensitivity to the contractions tended to decrease. Resveratrol increased nitrite/nitrate levels and suppressed basal or NAD(P)H-induced superoxide production and lipid peroxide levels in the aortas. Importantly, resveratrol increased serum insulin levels without affecting blood glucose and the lipid profile in diabetic rabbits. Using electron microscopic examinations, resveratrol was found to markedly protect the endothelial integrity from diabetes. Overall, there was no noticeable difference between resveratrol treatment groups on the recovery from diabetes. Our results indicate that resveratrol alleviates type 1 diabetes-induced vasculopathy by decreasing vascular oxidative stress and thereby increasing the bioavailability of nitric oxide without changing metabolic abnormalities.
dc.description.sponsorshipTUBITAK [105 S431]
dc.description.sponsorshipThis study was supported by a grant from TUBITAK 2008, Project No: 105 S431.
dc.identifier.doi10.1007/s10557-010-6255-7
dc.identifier.endpage131en_US
dc.identifier.issn0920-3206
dc.identifier.issn1573-7241
dc.identifier.issue2en_US
dc.identifier.pmid20676927
dc.identifier.scopusqualityQ1
dc.identifier.startpage119en_US
dc.identifier.urihttps://doi.org/10.1007/s10557-010-6255-7
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5567
dc.identifier.volume25en_US
dc.identifier.wosWOS:000290572200004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSPRINGER
dc.relation.ispartofCARDIOVASCULAR DRUGS AND THERAPY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectResveratrol
dc.subjectEndothelial and Vascular Function
dc.subjectSuperoxide
dc.subjectNitric Oxide
dc.subjectInsulin
dc.subjectAlloxan
dc.subjectDiabetic Rabbits
dc.titleResveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits
dc.typeArticle

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