Synthesis and characterization of Cu(II) complexes of 2-amino-6-sulfamoylbenzothiazole and their inhibition studies on carbonic anhydrase isoenzymes

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dc.contributor.authorAlkan Alkaya, Zeynep
dc.contributor.authorİlkimen, Halil
dc.contributor.authorYenikaya, Cengiz
dc.contributor.authorTunca, Ekrem
dc.contributor.authorBülbül, Metin
dc.contributor.authorTunç, Tuncay
dc.contributor.authorSarı, Musa
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:15:12Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:15:12Z
dc.date.issued2018
dc.departmentEğitim Fakültesi
dc.description.abstract2-Amino-6-sulfamoylbenzothiazole (SMABT) and its proton transfer compound (HSMABT)(+)(HDPC)(-) (1) with 2,6-pyridinedicarboxylic acid (H2DPC), and their Cu(II) complexes (2 of SMABT, 3 and 4 of 1) have been prepared and characterized by spectroscopic techniques. Additionally, single crystal X-ray diffraction techniques were applied to all complexes. All compounds, including acetazolamide (AAZ) as the control compound, were also evaluated for their in vitro inhibition effects on human hCA I and hCA II for their hydratase and esterase activities. The synthesized complexes have remarkable inhibitory effects on hCA I and hCA II isoenzymes. The inhibition potentials of the proton transfer salt (1) and the metal complexes (2-4) are comparable with AAZ. Esterase K-i values of the compounds (1-4) are in the range of 0.089 +/- 0.008 mu M-0.149 +/- 0.017 mu M for hCA I and 0.046 +/- 0.008 mu M-0.085 +/- 0.019 mu M for hCA II. Inhibition data have been analyzed by using a one-way analysis of variance for multiple comparisons (p < 0.0001). (C) 2018 Published by Elsevier Ltd.
dc.description.sponsorshipDumlupinar University Research Fund [2014/18]; Aksaray University of Science and Technology Application and Research Center [2010K120480]
dc.description.sponsorshipThe authors acknowledge the support provided by Dumlupinar University Research Fund (grant No. 2014/18). In addition, the authors acknowledge Aksaray University of Science and Technology Application and Research Center, for the use of the Bruker SMART BREEZE CCD diffractometer (purchased under grant No. 2010K120480 of the State of Planning Organization).
dc.identifier.doi10.1016/j.poly.2018.05.015
dc.identifier.endpage205en_US
dc.identifier.issn0277-5387
dc.identifier.scopusqualityQ2
dc.identifier.startpage199en_US
dc.identifier.urihttps://doi.org/10.1016/j.poly.2018.05.015
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4320
dc.identifier.volume151en_US
dc.identifier.wosWOS:000440125700023
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPolyhedron
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subject2-Amino-6-Sulfamoylbenzothiazole
dc.subjectProton Transfer
dc.subjectMetal Complex
dc.subjectCarbonic Anhydrase
dc.subjectStatistical Analyses
dc.titleSynthesis and characterization of Cu(II) complexes of 2-amino-6-sulfamoylbenzothiazole and their inhibition studies on carbonic anhydrase isoenzymes
dc.typeArticle

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