D-dimer levels as a procoagulative marker in association with disease progress during giardiasis in dogs

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dc.contributor.authorHaydardedeoglu, Ali Evren
dc.contributor.authorUral, Kerem
dc.contributor.authorOrman, Abdulkadir
dc.contributor.authorUral, Deniz Alic
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:38:13Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:38:13Z
dc.date.issued2018
dc.department[Haydardedeoglu, Ali Evren] Aksaray Univ, Dept Internal Med, Fac Vet Med, Aksaray, Turkey -- [Ural, Kerem] Adnan Menderes Univ, Dept Internal Med, Fac Vet Med, Aydin, Turkey -- [Orman, Abdulkadir] Uludag Univ, Dept Zootecn, Fac Vet Med, Bursa, Turkey -- [Ural, Deniz Alic] Adnan Menderes Univ, Fac Vet Med, Fac Farm, Aydin, Turkey
dc.description.abstractObjective. The present study was conducted to measure D-dimer concentrations and assess their value in disease activity in dogs with giardiasis. Furthermore another purpose was to analyze correlation between cyst excretion and D-dimer levels to those of dogs naturally infected with Giardia sp. Materials and methods. D-dimer analysis were performed in three groups of dogs; (i) 15 dogs with giardiasis to those of treated with secnidazol, (ii) 10 dogs with giardiasis, left untreated as control group, then were compared to those of (iii) 17dogs without giardiasis, used to detect reference ranges for D-dimer values as control group. was a correlation between D-dimer levels and logarythmic cyst counts. Results. The D-dimer range in healthy dogs was < 0.1 mg/L. In dogs with giardiasis, the D-dimer concentrations were greater than those of healthy dogs (p<0.05) and (p<0.01), respectively. The mean initial plasma D-dimer level was 2.84 +/- 0.50 and 2.99 +/- 0.61 ng/L in treated and untreated control groups. At the final follow-up evaluation on day 10 was 0.27 +/- 0.50 and 2.14 +/- 0.61 ng/L, in treated and untreated control groups, respectively, which was significantly lower in treated group (p<0.001). The area under curve (AUC) of the receiver operating characteristics for d-dimer was 0.922 (z-value = 12.977, p<0.0001). (95% CI: 0.780-0.885). At a cut-off value of 0.1 ng/L, the D-dimer measurement had a sensitivity of 87.2%, a specificity of 90.9%. Conclusions. As a result D-dimer concentrations measured in giardiasis support the probable link between probable pro-thrombotic and inflammatory condition.
dc.identifier.doi10.21897/rmvz.1348
dc.identifier.endpage6736en_US
dc.identifier.issn0122-0268
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage6726en_US
dc.identifier.urihttps://doi.org/10.21897/rmvz.1348
dc.identifier.urihttps://hdl.handle.net/20.500.12451/3714
dc.identifier.volume23en_US
dc.identifier.wosWOS:000444092000014
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversidad de Córdoba
dc.relation.ispartofRevista MVZ Córdoba
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectD-dimer
dc.subjectProcoagulation
dc.subjectInflammation
dc.subjectBiomarker
dc.subjectGiardiasis
dc.subjectDogs (Source: CAB)
dc.titleD-dimer levels as a procoagulative marker in association with disease progress during giardiasis in dogs
dc.typeArticle

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