Study of the anti(myco)bacterial and antitumor activities of prolinate and N-amidocarbothiolprolinate derivatives based on fused tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione, bearing an indole ring

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dc.authoridOzcelik, Nefise -- 0000-0002-6972-1071
dc.contributor.authorPoyraz, Samet
dc.contributor.authorCanacankatan, Necmiye
dc.contributor.authorBelveren, Samet
dc.contributor.authorYetkin, Derya
dc.contributor.authorKibar, Kezban
dc.contributor.authorÜlger, Mahmut
dc.contributor.authorSansano, Jose M.
dc.contributor.authorDilek Özçelik, Nefise
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:15:11Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:15:11Z
dc.date.issued2018
dc.departmentFen-Edebiyat Fakültesi
dc.description.abstractA series of prolinate and N-amidocarbothiolprolinate derivatives based on a fused pyrrole-3,4-dione core, bearing indole ring systems, are prepared from the corresponding amino acid and an aldehyde via thermal 1,3-dipolar cycloaddition of azomethine ylides and condensation with benzoylisothiocyanate. Products are fully characterized by NMR, FT-IR, MS, and an X-ray crystal structure. The prepared compounds are screened for their antibacterial activity against a range of Gram-positive and Gram-negative bacteria and their antimycobacterial activity against M. tuberculosis H37Rv strain. In addition, two selected target compounds are evaluated for cytotoxicity, apoptosis, and anti-inflammatory effects on MCF-7 (breast carcinoma) cell lines. The incorporation of indole ring and -C(O)NHC(S)- moiety resulted to be beneficial since the biological point of view. [GRAPHICS]
dc.description.sponsorshipMersin University, Research Foundation [BAP 2015-AP2-1342]
dc.description.sponsorshipWe would like to thank Mersin University, Research Foundation (Project No: BAP 2015-AP2-1342) for financial support.
dc.identifier.doi10.1007/s00706-018-2286-8
dc.identifier.endpage2263en_US
dc.identifier.issn0026-9247
dc.identifier.issn1434-4475
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage2253en_US
dc.identifier.urihttps://doi.org/10.1007/s00706-018-2286-8
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4316
dc.identifier.volume149en_US
dc.identifier.wosWOS:000449934300013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSPRINGER WIEN
dc.relation.ispartofMONATSHEFTE FUR CHEMIE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAmino Acids
dc.subjectCycloadditions
dc.subjectHeterocycles
dc.subjectMCF-7 Cells
dc.subjectApoptosis
dc.subjectAnti(myco)bacterial
dc.titleStudy of the anti(myco)bacterial and antitumor activities of prolinate and N-amidocarbothiolprolinate derivatives based on fused tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione, bearing an indole ring
dc.typeArticle

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