Study of the anti(myco)bacterial and antitumor activities of prolinate and N-amidocarbothiolprolinate derivatives based on fused tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione, bearing an indole ring
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Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
SPRINGER WIEN
Access Rights
info:eu-repo/semantics/embargoedAccess
Abstract
A series of prolinate and N-amidocarbothiolprolinate derivatives based on a fused pyrrole-3,4-dione core, bearing indole ring systems, are prepared from the corresponding amino acid and an aldehyde via thermal 1,3-dipolar cycloaddition of azomethine ylides and condensation with benzoylisothiocyanate. Products are fully characterized by NMR, FT-IR, MS, and an X-ray crystal structure. The prepared compounds are screened for their antibacterial activity against a range of Gram-positive and Gram-negative bacteria and their antimycobacterial activity against M. tuberculosis H37Rv strain. In addition, two selected target compounds are evaluated for cytotoxicity, apoptosis, and anti-inflammatory effects on MCF-7 (breast carcinoma) cell lines. The incorporation of indole ring and -C(O)NHC(S)- moiety resulted to be beneficial since the biological point of view. [GRAPHICS]
Description
Keywords
Amino Acids, Cycloadditions, Heterocycles, MCF-7 Cells, Apoptosis, Anti(myco)bacterial
Journal or Series
MONATSHEFTE FUR CHEMIE
WoS Q Value
N/A
Scopus Q Value
Q2
Volume
149
Issue
12
