Antioxidative and antiproliferative effects of propolis-reduced silver nanoparticles

Basit Öğe Kaydı
dc.contributor.authorTan, Gamze
dc.contributor.authorİlk, Sedef
dc.contributor.authorFoto, Fatma Z.
dc.contributor.authorFoto, Egemen
dc.contributor.authorSağlam, Necdet
dc.date.accessioned2021-05-25T06:50:27Z
dc.date.available2021-05-25T06:50:27Z
dc.date.issued2021
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.descriptionTan, Gamze ( Aksaray, Yazar )
dc.description.abstractIn this study, phytochemicals present in Propolis Extract (PE) were employed as reducing and stabilizing reagents to synthesize silver nanoparticles. Three propolis-reduced silver nanoparticles (P-AgNPs1-3) were synthesized using increasing amounts of PE. P-AgNPs were treated with different cancer cells -lung (A549), cervix (HeLa) and colon (WiDr) for 24, 48 and 72 h to evaluate their anti -proliferative activities. A non-cancerous cell type (L929) was also used to test whether suppressive effects of P-AgNPs on cancer cell proliferation were due to a general cytotoxic effect. The characterization results showed that the bioactive contents in propolis successfully induced particle formation. As the amount of PE increased, the particle size decreased; however, the size distribution range expanded. The antioxidant capacity of the particles increased with increased propolis amounts. P-AgNP1 exhibited almost equal inhibitory effects across all cancer cell types; however, P-AgNP2 was more effective on HeLa cells. P-AgNPs3 showed greater inhibitory effects in almost all cancer cells compared to other NPs and pure propolis. Consequently, the biological effects of P-AgNPs were highly dependent on PE amount, NP concentration, and cell type. These results suggest that AgNPs synthesized utilizing propolis phytochemicals might serve as anti -cancer agents, providing greater efficacy against cancer cells.
dc.identifier.doi10.12989/anr.2021.10.2.139
dc.identifier.endpage150en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage139en_US
dc.identifier.urihttps:/dx.doi.org/10.12989/anr.2021.10.2.139
dc.identifier.urihttps://hdl.handle.net/20.500.12451/7963
dc.identifier.volume10en_US
dc.identifier.wosWOS:000643257800004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTechno Press
dc.relation.ispartofAdvances in Nano Research (ANR)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPropolis
dc.subjectsilver Nanoparticles
dc.subjectDPPH
dc.subjectSRB Assay
dc.subjectAnti -cancer Activity
dc.subjectCytotoxicity
dc.titleAntioxidative and antiproliferative effects of propolis-reduced silver nanoparticles
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu