The preparation of chitosan membrane improved with nanoparticles based on unsaturated fatty acid for using in cancer-related infections

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dc.contributor.authorKızaloğlu, Abdullah
dc.contributor.authorKılıçay, Ebru
dc.contributor.authorKarahalilo?lu, Zeynep
dc.contributor.authorHazer, Baki
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned2020-09-22T06:01:05Z
dc.date.available2020-09-22T06:01:05Z
dc.date.issued2020
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.descriptionKarahalilo?lu, Zeynep ( Aksaray, Yazar )
dc.description.abstractThis study includes the design of a chitosan membrane decorated with unsaturated fatty acid–based carrier system for cancer treatment and antibacterial application. For this, polystyrene-graft-polyoleic acid-graft-polyethylene glycol was prepared by free radical polymerization and characterized. Nanoparticles and caffeic acid–loaded nanoparticles were prepared by solvent evaporation technique and optimized. The short-term stability of nanoparticles was investigated at 4°C. Drug encapsulation and loading efficiency were evaluated. The chitosan membrane and caffeic acid–loaded nanoparticles embedded into chitosan membrane were fabricated. The caffeic acid loaded nanoparticles embedded into chitosan membrane showed controlled release. The mechanical properties of all samples were investigated. The caffeic acid–loaded nanoparticles embedded into chitosan membranes indicated excellent antibacterial properties against the Escherichia coli and Staphylococcus aureus. The anticancer activity of all the samples was evaluated against SaOS-2 human primary osteogenic sarcoma and MC3T3-E1 pre-osteoblast cell lines by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay, the flow cytometry and double staining methods. As a result, the designed carrier system showed great potential to cancer-associated infections treatment in bone cancer cases.
dc.identifier.doi10.1177/0883911520943222
dc.identifier.endpage350en_US
dc.identifier.issn0883-9115
dc.identifier.issue4-5en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage328en_US
dc.identifier.urihttps:/dx.doi.org/10.1177/0883911520943222
dc.identifier.urihttps://hdl.handle.net/20.500.12451/7679
dc.identifier.volume35en_US
dc.identifier.wosWOS:000563036900004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSAGE Publications Ltd
dc.relation.ispartofJournal of Bioactive and Compatible Polymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCancer-associated Infections
dc.subjectCaffeic Acid
dc.subjectChitosan
dc.subjectOleic Acid
dc.subjectNanoparticle
dc.titleThe preparation of chitosan membrane improved with nanoparticles based on unsaturated fatty acid for using in cancer-related infections
dc.typeArticle

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