Impact of sublethal di-n-butyl phthalate on the aquaculture fish species Nile tilapia (Oreochromis niloticus): histopathology and oxidative stress assessment

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dc.authoridAgus, Hızlan Hıncal -- 0000-0002-0252-9501
dc.contributor.authorErkmen, Belda
dc.contributor.authorBenli, A. Cağlan Karasu
dc.contributor.authorAgus, Hızlan Hıncal
dc.contributor.authorYıldırım, Zuhal
dc.contributor.authorMert, Ramazan
dc.contributor.authorErkoç, Figen
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:30:09Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:30:09Z
dc.date.issued2017
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractPhthalates such as di-n-butyl phthalate (DBP) and their esters are widely used plasticizers, their ubiquitous presence in daily life, inevitably leads to their restricted use due to important environmental pollution and health impacts and endocrine disruption potential. The aim of this study was to examine the effects of a sublethal concentration of 10 mg L-1 DBP on haematocrit (HCT) values, gills and liver histology, malondialdehyde (MDA, 2-thiobarbituric acid-TBA reactivity) and reduced glutathione (GSH) levels in gills and liver tissue as oxidative stress biomarkers in the aquaculture fish species Nile tilapia (Oreochromis niloticus) after 24 (DBP-24) and 96 (DBP-96) h exposure. No differences were found between per cent HCT values in the 24 h exposure groups (P > 0.05). Response of antioxidant defence systems in liver and gill tissues of the fish were dependent on exposure duration and changed to a higher extent during 96 h. MDA levels in liver tissue increased in DBP treated fish in comparison to the control fish. However, the differences between the exposure and control groups were not significant (P > 0.05). A statistically significant decrease (P > 0.05) was recorded in gill MDA levels in the DBP-96 group when compared to the control and DBP-24 groups. The liver GSH levels were unchanged in the DBP treated fish. However, GSH levels were significantly lower in the gill tissue of the DBP-96 group. Exposure to DBP caused several degenerative changes in the histology of gill and liver tissue. Gills displayed hyperaemia, epithelial lifting, oedema, talengiectasia, epithelial hyperplasia and fusion of secondary lamellae, whereas in liver several circulatory anomalies (hyperaemia, blood congestion and sinosoid dilatation) and vacuolization of hepatocytes were observed. Histopathological results demonstrated that the gills were more affected than the liver perhaps due to their direct contact with DBP.
dc.identifier.doi10.1111/are.12914
dc.identifier.endpage685en_US
dc.identifier.issn1355-557X
dc.identifier.issn1365-2109
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage675en_US
dc.identifier.urihttps://doi.org/10.1111/are.12914
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6244
dc.identifier.volume48en_US
dc.identifier.wosWOS:000391960400028
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofAquaculture Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDBP
dc.subjectdi-n-butyl phthalate
dc.subjectHistopathology
dc.subjectOxidative Stress Biomarkers
dc.subjectNile Tilapia
dc.subjectOreochromis Niloticus
dc.titleImpact of sublethal di-n-butyl phthalate on the aquaculture fish species Nile tilapia (Oreochromis niloticus): histopathology and oxidative stress assessment
dc.typeArticle

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