Genotoxicity of sub-lethal di-n-butyl phthalate (DBP) in Nile tilapia (Oreochromis niloticus)

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dc.contributor.authorKarasu Benli, Aysel Çağlan
dc.contributor.authorErkmen, Belda
dc.contributor.authorErkoç, Figen
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:28:18Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:28:18Z
dc.date.issued2016
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThis study aimed to assess genotoxicity in Nile tilapia (Oreochromis niloticus) erythrocytes after exposure to a sub-lethal concentration of 10 mg L-1 di-n-butyl phthalate (DBP) for 24 and 96 h. The results showed that mean MN frequencies in both DBP and ethyl methane-sulfonate (EMS, positive control for MN bioassay) groups were significantly different (p<0.01) with respect to control and solvent control groups, in both exposure scenarios. When analysing nuclear abnormalities, the frequency of notched nuclei was significantly different (p<0.05) but the frequencies of other subtypes did not change. The 96-h exposure led to an increase in the mean frequencies of notched nuclei, and also caused significant differences between MN frequencies in all groups (p<0.01). Our findings indicate that sub-lethal DBP concentrations when tested in controlled laboratory conditions have genotoxic potential towards Nile tilapia. Further detailed studies should be done for the determination of the environmental risk assessment for aquatic life since DBP is a high risk contaminant of freshwater and marine ecosystems.
dc.identifier.doi10.1515/aiht-2016-67-2723
dc.identifier.endpage30en_US
dc.identifier.issn0004-1254
dc.identifier.issn1848-6312
dc.identifier.issue1en_US
dc.identifier.pmid27092636
dc.identifier.scopusqualityQ2
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.1515/aiht-2016-67-2723
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6019
dc.identifier.volume67en_US
dc.identifier.wosWOS:000377687600004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInst Medical Research & Occupational Health
dc.relation.ispartofArhiv Za Higıjenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBioassay
dc.subjectGenotoxicity
dc.subjectNotched Nuclei
dc.subjectPhthalates
dc.titleGenotoxicity of sub-lethal di-n-butyl phthalate (DBP) in Nile tilapia (Oreochromis niloticus)
dc.typeArticle

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