Evaluation of potential anti-aging effects of Achillea phrygia Boiss. & Balansa (Asteraceae)
| dc.authorid | 0000-0003-2395-2445 | |
| dc.authorid | 0000-0001-7676-542X | |
| dc.authorid | 0000-0002-5188-1106 | |
| dc.contributor.author | Gülen, Rukiye Boran | |
| dc.contributor.author | Saraç, Nurdan | |
| dc.contributor.author | Uğur, Aysel | |
| dc.date.accessioned | 2025-02-24T12:39:26Z | |
| dc.date.available | 2025-02-24T12:39:26Z | |
| dc.date.issued | 2024 | |
| dc.department | Sağlık Hizmetleri Meslek Yüksekokulu | |
| dc.description.abstract | This study aims to determine the anti-aging effects of Achillea phrygia, an endemic plant, by evaluating its sun protection factor (SPF) level, antioxidant activity, total phenolic content, extracellular matrix-degrading enzymes (ECM) inhibition, genotoxic/anti-genotoxic, and cytotoxic activities. The SPF level was assessed using an in vitro quantitative method, while antioxidant capacity was determined through DPPH, ?-carotene, and hydroxyl-radical (H2O2) scavenging assays. The total phenolic content was quantitatively conducted using the Folin Ciocalteu reagent. The inhibition of ECM-degrading enzymes was determined using matrix metalloproteinase-1 (MMP-1), hyaluronidase, and elastase enzymes. Genotoxic/anti-genotoxic properties were assessed using the AMES Salmonella/microsome assay, and cytotoxicity effects were assessed through the MTT assay. The results indicated that A. phrygia showed moderate SPF activity (SPF = 4.013) and exhibited IC50 values of 0.183 ± 0.03, 0.079 ± 0.51, and 1.18 ± 0.35 mg/mL for DPPH, ?-carotene, and hydroxyl-radicals, respectively. The total phenolic content was measured to be 23.56 ± 1.42 mg GAE/g dry extract. Furthermore, the extract demonstrated inhibition of MMP-1 (47.98%) and elastase (39.2%) activities. Importantly, it did not induce DNA damage and showed antigenotoxic activity ranging from 10% to 65.6%. The cytotoxicity assay revealed an IC50 value of 42.41±4.05 µg/mL. These findings suggest that A. phrygia could be utilized as a cosmetic ingredient in skincare products due to its ability to protect against UV radiation, exhibit antioxidant properties, prevent extracellular matrix degradation, and inhibit DNA damage. | |
| dc.identifier.doi | 10.21448/ijsm.1401681 | |
| dc.identifier.endpage | 657 | en_US |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 646 | en_US |
| dc.identifier.uri | https://dx.doi.org/10.21448/ijsm.1401681 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/12952 | |
| dc.identifier.volume | 11 | en_US |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | |
| dc.publisher | Pamukkale University | |
| dc.relation.ispartof | International Journal of Secondary Metabolite | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Achillea Phrygia | |
| dc.subject | Skin-care | |
| dc.subject | Antioxidant | |
| dc.subject | Enzyme Inhibition | |
| dc.subject | Anti-genotoxicity | |
| dc.title | Evaluation of potential anti-aging effects of Achillea phrygia Boiss. & Balansa (Asteraceae) | |
| dc.type | Article |
