Anti-cancer effect of Thymus vulgaris based synthesized gold nanoparticles in giant macroporous silica: impact on MCF-7 breast cancer cells

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dc.authorid0000-0002-4415-6803
dc.contributor.authorKoç Bilican, Behlül
dc.contributor.authorBenarous, Samiha
dc.contributor.authorKoca, Fatih Dogan
dc.contributor.authorCansaran-Duman, Demet
dc.contributor.authorSørensen, Martin Vinther
dc.contributor.authorBilican, Ismail
dc.contributor.authorKaya, Murat
dc.date.accessioned2025-07-18T07:42:21Z
dc.date.available2025-07-18T07:42:21Z
dc.date.issued2025
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractConventional cancer therapies, while effective, are frequently associated with significant adverse effects owing to their lack of selectivity, impacting both malignant and healthy cells. To address these challenges, gold nanoparticles (AuNPs) have emerged as a promising platform for targeted drug delivery. Giant macroporous silica (GMS) is a recently developed material, with its drug delivery potential explored in only a single study to date. In this study, gold nanoparticles (AuNPs) synthesized using Thymus vulgaris (garden thyme) extract were incorporated into GMS, forming GMS-AuNPs. Additionally, AuNPs coated with chitosan (AuNPs@CS) were similarly loaded into GMS, resulting in GMS-AuNPs@CS composites. The synthesized materials were characterized through light microscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The anti-cancer effects of GMS-AuNPs and GMS-AuNPs@CS were assessed against breast cancer cells using real-time cell analysis. Notably, no cytotoxic effects were observed on MCF-12 A normal breast epithelial cells at any of the tested concentrations. GMS-AuNPs demonstrated a dose- and time-dependent cytotoxic effect on breast cancer cells. These findings suggest that GMS-AuNPs hold promise as a potential therapeutic strategy for breast cancer treatment.
dc.identifier.doi10.1007/s41779-025-01164-5
dc.identifier.issn25101560
dc.identifier.scopus85218262829
dc.identifier.urihttps://dx.doi.org/10.1007/s41779-025-01164-5
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13374
dc.identifier.wosWOS:001426414700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorKoç Bilican, Behlül
dc.institutionauthorBilican, İsmail
dc.institutionauthorid0000-0002-4415-6803
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of the Australian Ceramic Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreast Cancer (MCF-7)
dc.subjectGiant Macroporous Silica
dc.subjectGold Nanoparticles
dc.subjectThymus Vulgaris
dc.titleAnti-cancer effect of Thymus vulgaris based synthesized gold nanoparticles in giant macroporous silica: impact on MCF-7 breast cancer cells
dc.typeArticle

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