Phenolic extracts of zizyphus lotus l. (rhamnaceae) and ruta chalepensis l. (rutaceae) as alternatives to antibiotics and their antimicrobial effects on clinical multidrug resistant pathogen

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dc.authorid0000-0002-1194-3472
dc.authorid0000-0001-7946-012X
dc.authorid0000-0001-8502-8982
dc.authorid0000-0003-0118-9151
dc.contributor.authorBekkar, Nour El Houda
dc.contributor.authorBoumediene, Meddah
dc.contributor.authorÇakmak, Yavuz Selim
dc.contributor.authorKeskin, Bahadır
dc.contributor.authorSonnet, Pascal
dc.date.accessioned2025-09-10T07:20:01Z
dc.date.available2025-09-10T07:20:01Z
dc.date.issued2022
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThe phytochemical composition and the antibacterial and antifungal properties of Zizyphus lotus L. (ZL) leaves and Ruta chalepensis L. (RC) aerial parts harvested from Oran in northwest Algeria were assessed against multidrug-resistant (MDR) clinical pathogens. Materials and Methods: The phenolic compounds identification in the hydromethanolic (MeOH.E) and the aqueous extracts (Aq. E) was done by HPLC-DAD analysis, while the phenolic, flavonoid and tannin contents were determined using quantitative methods. The antibacterial and antifungal activities were also determined. The synergistic effect between both plants was elucidated using the checkerboard dilution test. Results: An important phenolic content was determined with higher concentrations in Z. lotus leaves extracts than R. chalepensis. The HPLC-DAD analysis allowed us to identify benzoic acid as the major phenolic compound in Z. lotus extracts, while catechin, quercetin and epicatechin were the major compounds identified in R. chalepensis. Important antimicrobial activity was observed against all the clinical pathogen strains. The most potent effect was estimated against MDR Salmonella enterica sp. arizonae with 20±0.1mm of growth inhibition zone diameter using RCMeOH.E, while a diameter of 35.03±0.06 mm was measured using ZLMeOH.E. Also, important anti-Candida activity was estimated. No synergistic interaction against the different microbial strains was determined by applying the combinations of both plants' extracts, with a fractional inhibitory concentration index superior to 4 (FICindex >4). Conclusion: Z. lotus and R. chalepensis can be exploited in the medical field as a potential source of antimicrobial components.
dc.identifier.doi10.26650/EurJBiol.2022.1129558
dc.identifier.endpage183
dc.identifier.issn2618-6144
dc.identifier.issue2
dc.identifier.startpage163
dc.identifier.urihttps://doi.org/10.26650/EurJBiol.2022.1129558
dc.identifier.urihttps://hdl.handle.net/20.500.12451/14272
dc.identifier.volume81
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorÇakmak, Yavuz Selim
dc.institutionauthorid0000-0001-8954-5485
dc.language.isoen
dc.publisherİstanbul Üniversitesi Yayınevi
dc.relation.ispartofEuropean Journal of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntibiotic Alternatives
dc.subjectAntimicrobial Activity
dc.subjectMultidrug-resistant Pathogens
dc.subjectPhenolic Compounds
dc.subjectR. chalepensis
dc.subjectZ. lotus
dc.titlePhenolic extracts of zizyphus lotus l. (rhamnaceae) and ruta chalepensis l. (rutaceae) as alternatives to antibiotics and their antimicrobial effects on clinical multidrug resistant pathogen
dc.typeArticle

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