Investigations of anti-aging potential of Hypericum origanifolium Willd. for skincare formulations

Basit Öğe Kaydı
dc.authoridBoran, Rukiye -- 0000-0003-2395-2445
dc.contributor.authorBoran, Rukiye
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:15:13Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:15:13Z
dc.date.issued2018
dc.departmentSağlık Hizmetleri Meslek Yüksekokulu
dc.description.abstractSkin aging is caused by increased activation of extracellular matrix disruption enzymes, oxidative stress and DNA damage. Inhibition of these mechanisms by natural plants may be an encouraging approach to prevent skin aging. Hypericum is medically important plant and a source of several promising compounds. Nevertheless, there are no studies about the anti-aging potential of Hypericum origanifolium Willd (Guttiferae). The purpose of this study was to research the anti-collagenase, anti-elastase and anti-hyaluronidase effects, together with the antioxidant and genotoxic/antigenotoxic activities of H. origanifolium. Ethanol extract of H. origanifolium harvested from Turkey was tested for anti-collagenase, anti-elastase and anti-hyaluronidase activities. The extract inhibited collagenase and elastase activity. The highest ECM-degrade enzyme inhibition was demonstrated against collagenase (79.39%). The phenolic constituent and antioxidant activity were tested by Folin-Ciocalteu method (FCM), 2,2-dipenyl-1-picrylhydrazyl (DPPH) radical-scavenging and beta-carotene bleaching assay. The total phenol content revealed to be 93.4 +/- 1.6 mg GAE/g dry extract. IC50 values observed in DPPH and beta-carotene bleaching assays were 270 +/- 0.1 and 230 +/- 0.2 mu g/mL, respectively. Finally, the extract was investigated for its genotoxic/antigenotoxic effects using Ames Salmonella/microsome test system. Results indicated no sign of mutagenicity, and depending upon the concentration, the antigenotoxicity was noted with an inhibition of mutagenicity going from 21.54 to 84.90%. The results suggest that H. origanifolium can be considered as new natural sources to be potentially used as anti-aging ingredients in skin care formulations.
dc.identifier.doi10.1016/j.indcrop.2018.03.058
dc.identifier.endpage295en_US
dc.identifier.issn0926-6690
dc.identifier.issn1872-633X
dc.identifier.scopusqualityQ1
dc.identifier.startpage290en_US
dc.identifier.urihttps://doi.org/10.1016/j.indcrop.2018.03.058
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4324
dc.identifier.volume118en_US
dc.identifier.wosWOS:000433269500033
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofIndustrial Crops and Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHypericum Origanifolium
dc.subjectAnti-aging
dc.subjectEnzyme Inhibition
dc.subjectAntioxidant
dc.subjectAntigenotoxicity
dc.titleInvestigations of anti-aging potential of Hypericum origanifolium Willd. for skincare formulations
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
boran-rukiye-2018.pdf
Boyut:
269.42 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu