Black cumin may be a potential drug for development of carbontetrachloride-induced lung damage in rats

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dc.contributor.authorAslan, Abdullah
dc.contributor.authorBoydak, Didem
dc.contributor.authorCan, Muhammed İsmail
dc.contributor.authorKuloğlu, Tuncay
dc.contributor.authorBaşpınar, Serpil
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:22:00Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:22:00Z
dc.date.issued2016
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThe study examines whether Black cumin (Nigella sativa L.) plays a protective role against the damage in the lung by administering carbontetrachloride (CCl4) to rats. 28 male Wistar albino (n=28, 8 weeks old) rats were used in the study. The rats divided into 4 groups according to their live weights. The groups were: (i) Negative Control (NC): Normal water consuming group to which no CCl4 and Black cumin (BC) is administered; (ii) Positive Control (PC): Normal water consuming group to which no CCl4 is administered but BC is administered; (iii) CCl4 Group: Normal water consuming and group to which CCl4 is administered (1.5 ml/kg live weight, ip); (iv) CCl4 + BC group: CCl4 and BC administered group (1.5 ml/kg live weight, ip). Tissue apoptotic index was examined via TUNEL method. MDA (malondialdehyde) determination in lung tissue was made using spectrophotometer. As a results, MDA amount decreased in the CCl4 + BC group (6,33 ± 1,54 nmol/g) in comparison to CCl4 group (8,66 ± 1,58 nmol/g) whereas it was observed in the CCl4+BC group (15,35 ± 0,21%) that the apoptotic index (TUNEL results) decreases in comparison with the CCl4 group (27,48 ± 0,28%) thus approaching normal values. DNA damage ratio decreased in the CCl4 + BC group in comparison to CCl4 group. These results show that BC plant protects the lung against oxidative damage. © Mattioli 1885.
dc.identifier.endpage62en_US
dc.identifier.issn1129-8723
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage56en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12451/2432
dc.identifier.volume18en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMattioli 1885 S.p.A.
dc.relation.ispartofProgress in Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectDNA Damage
dc.subjectLung
dc.subjectNew Drug
dc.subjectTUNEL
dc.titleBlack cumin may be a potential drug for development of carbontetrachloride-induced lung damage in rats
dc.typeArticle

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